Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranes

Bioelectrochemistry

Volumn 54, Issue 1, 2001, Pages 11-15

  Grigoriev, P A ^a   Schlegel, R ^b   Grafe U ^b  

^a INSTITUTE OF CELL BIOPHYSICS   (Russian Federation)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Antibiotic elaiophylin; Bilayer lipid membrane; Ion channels; Ion selectivity

Indexed keywords

ANTIBIOTICS; ELECTROLYTES; ION SELECTIVE MEMBRANES; POSITIVE IONS;

ION CHANNELS;

LIPIDS;

ANTIBIOTIC AGENT; CATION CHANNEL; CESIUM CHLORIDE; ELAIOPHYLIN; ELECTROLYTE; LITHIUM CHLORIDE; PHOSPHATIDYLCHOLINE; POTASSIUM CHLORIDE; RUBIDIUM CHLORIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONDUCTANCE; DRUG STRUCTURE; LIPID BILAYER; LIPID MEMBRANE; MEMBRANE CURRENT; MEMBRANE PERMEABILITY; MOLECULAR MODEL; NONHUMAN; SOYBEAN;

ANTI-BACTERIAL AGENTS; CATIONS; ION CHANNEL GATING; ION CHANNELS; LIPID BILAYERS; MACROLIDES; MEMBRANE POTENTIALS; MEMBRANES, ARTIFICIAL;

GLYCINE MAX;

EID: 0034906256     PISSN: 15675394     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0302-4598(01)00102-7     Document Type: Article

References (10)

1. Isolation and characterization of niphimycins A, B, and elaiophylin, antibiotics produced by Streptomyces violaceoniger
2. New macrodiolide antibiotics, 11-O-monomethyl- and 11,11-O-dimethyl-elaiophylins from Streptomyces sp. HKI-0113 and HKI-0114
3. Mechanism of anion-cation selectivity of amphotericin B channels
4. Structural requirements for pore formation in alamethicins and analogs
5. An alamethicin channel in a lipid bilayer: Molecular dynamic simulations
6. Formation of membrane channnels by chrysospermins, new peptaibol antibiotics
7. How do ionic channel properties depend on the structure of polyene antibiotic molecule?
8. Single length and double length channels formed by nystatin in lipid bilayer membranes
9. Hofmeister effect in ion transport: Reversible binding of halide anions to the roflamycoin channel
10. The barrel-stage model as applied to alamethicin and its analogs reevaluated