Novel drug delivery system to bone using acidic oligopeptide: Pharmacokinetic characteristics and pharmacological potential

Journal of Drug Targeting

Volumn 9, Issue 2, 2001, Pages 111-121

  Sekido, T ^a   Sakura, N ^a   Higashi, Y ^a   Miya, K ^a   Nitta, Y ^a   Nomura, M ^a   Sawanishi, H ^a   Morito, K ^a   Masamune, Y ^a   Kasugai, S ^a   Yokogawa, K ^a   Miyamoto, K I ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Acidic amino acid; Aspartate; Bone; Drug delivery system; Estradiol; Hydroxyapatite; Oligopeptide

Indexed keywords

9 FLUORENYLMETHYL CHLOROFORMATE; ASPARTIC ACID; ESTRADIOL; ESTRADIOL 17BETA SUCCINATE ASPARTATE HEXAPEPTIDE; GLUTAMIC ACID; HEXAPEPTIDE; HYDROXYAPATITE; OLIGOPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE; BONE ATROPHY; BONE DENSITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; FEMALE; IN VITRO STUDY; MOUSE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; UTERUS WEIGHT;

EID: 0034903137     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611860108997922     Document Type: Article

References (16)

1. The nature and significance of osteopontin
2. Bisphosphonates: History and experimental basis
3. Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. I: Synthesis and in vivo characterization of osteotropic carboxyfluorescein
4. Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. IV: Effects of osteotropic estradiol on bone mineral density and uterine weight in ovariectomized rats
5. Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug. V: Biological disposition and targeting characteristics of osteotropic estradiol
6. Preferential adsorption of dentin and bone acidic proteins on the (100) face of hydroxyapatite crystals
7. Acidic amino acid-rich sequence as binding sites of osteonectin to hydroxyapatite crystals
8. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
9. Adsorption and modification of calcium salt crystal growth by anionic peptides and spermine
10. Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence
11. The primary structure of a cell-binding bone sialoprotein
12. The osteoporosis revolution
13. Bisphosphonate action
14. Treatment of osteoporosis with bisphosphonates
15. Estrogens and progestins
16. Statistical moments in pharmacokinetics