Localization of metallothionein in urothelial carcinoma of the human urinary bladder: An immunohistochemical study including correlation with HLA-DR antigen, p53, and proliferation indices

Anticancer Research

Volumn 21, Issue 3 B, 2001, Pages 1757-1761

  Ioachim, E E ^a   Charchanti, A V ^a   Stavropoulos, N E ^a   Athanassiou, E D ^a   Michael, M C H R ^a   Agnantis, N J ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

Author keywords

Bladder cancer; HLA DR PCNA; Metallothionein; MIB1; P53

Indexed keywords

CYCLINE; HLA DR ANTIGEN; METALLOTHIONEIN; MONOCLONAL ANTIBODY E91; MONOCLONAL ANTIBODY KI 67; PROTEIN P53;

ADULT; AGE; AGED; ARTICLE; BLADDER CARCINOMA; CANCER GRADING; CANCER RECURRENCE; CANCER STAGING; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ASSAY; SEX; SQUAMOUS CELL METAPLASIA;

AGE FACTORS; AGED; ANTIBODIES, MONOCLONAL; CARCINOMA; CELL DIVISION; EPITOPES; FEMALE; HLA-DR ANTIGENS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; METALLOTHIONEIN; MIDDLE AGED; PROTEIN ISOFORMS; SEX FACTORS; TUMOR SUPPRESSOR PROTEIN P53; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 0034898449     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Overview of metallothionein
2. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium
3. Metallothionein
4. Progesterone induction of metallothionein-IIA gene expression
5. Distribution of metallothionein in normal and pathological human skin
6. Immunohistochemical detection of metallothionein
7. Immunohistochemical localization of metallothionein in human thyroid tumors
8. Human fetal liver contains both zinc and copper-rich forms of metallothionein
9. Preparation and properties of the major copper-binding component in human fetal liver
10. Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney
11. Localisation of metallothionein in breast carcinomas. An immunohistochemical study
12. Immunohistochemical detection of metallothionein in primary breast carcinomas and their axillary lymph node metastasis
13. Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast
14. Metallothionein expression in duct carcinoma in situ of the breast
15. Immunohistochemically demonstrated metallothionein expression in malignant melanoma
16. Immunohistochemical study of metallothionein in pancreatic carcinomas
17. Immunohistochemical metallothionein expression in colorectal adenocarcinoma: Correlation with tumor stage and patient survival
18. National Cancer Institute workshop on the possible roles of metallothionein in carcinogenesis
19. A structural role for metal ions in the "wildtype" conformation of the tumour suppressor protein p53
20. Thionein (apothionein) can modulate DNA binding and transcription activation by zinc finger containing factor SP1
21. Anti-sense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells
22. Absence of immunohistochemical metallothionein staining in bladder tumor specimens predicts response to neoadjuvant cisplastin, methotrexate and vinblastine chemotherapy
23. Over-expression of metallothionein and drug-resistance in bladder cancer
24. Histopathological study of metallothionein in bladder cancer and renal cell carcinoma
25. The World Health Organization/International Society of Urological Pathology Consensus Classification of urothelial (transitional cell) Neoplasms of the urinary bladder
26. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabelled antibody (PAP) procedures
27. Clonal overexpression of metallothionein is induced by somatic mutation in morphologically normal colonic mucosa
28. Immunohistochemical localization of metallothionein in transitional cell carcinoma of the bladder
29. HLA-DR antigen expression and lymphocyte subsets in transitional cell carcinoma of the urinary bladder. An immunohistological study on frozen sections
30. p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression
31. p53 and erb-2 protein overexpression are associated with early invasion and metastasis in bladder cancer
32. p53 but not erbB-2 expression is associated with rapid tumor proliferation in urinary bladder cancer
33. Over-expression of p53 nuclear oncoprotein in transitional cell bladder cancer and its prognostic value
34. p53 and c-jun expression in urinary bladder transitional cell carcinoma: Correlation with proliferating cell nuclear antigen (PCNA) histological grade and clinical stage