In vitro hemolysis and buffer capacity studies with the novel marine anticancer agent kahalalide F and its reconstitution vehicle cremophor EL/ethanol

PDA Journal of Pharmaceutical Science and Technology

Volumn 55, Issue 4, 2001, Pages 223-229

  Nuijen, B ^a   Bouma, M ^a   Manada, C ^a   Jimeno, J M ^a   Bult, A ^a   Beijnen, J H ^a  

^a SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

Anticancer agent; Biocompatibility; Buffer capacity; Cremophor; EL; Ethanol; FB ratio; Hemolysis; Kahalalide F

Indexed keywords

ALCOHOL; ANTINEOPLASTIC AGENT; BUFFER; CITRIC ACID; CREMOPHOR; DRUG VEHICLE; KAHALALIDE F; POLYSORBATE 60; UNCLASSIFIED DRUG;

ARTICLE; BIOCOMPATIBILITY; DRUG FORMULATION; DRUG STRUCTURE; HEMOLYSIS; IN VITRO STUDY; LYOPHILISATE; PH;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOCOMPATIBLE MATERIALS; BUFFERS; CHEMISTRY, PHARMACEUTICAL; DEPSIPEPTIDES; ETHANOL; GLYCEROL; HEMOLYSIS; HYDROGEN-ION CONCENTRATION; PEPTIDES; RATS; VEHICLES;

EID: 0034897461     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Preclinical pharmacology studies with the marine natural product kahalalide F
2. Preclinical development of kahalalide F, a new marine compound selected for clinical studies
3. Pharmaceutical development of (investigational) anticancer agents for parenteral use - A review
4. Solubility principles and practices for parenteral drug dosage form development
5. Parenteral formulations of small molecules therapeutics marketed in the United States (1999) part II and III
6. Phase I clinical and pharmacokinetic investigation of didemnin B, a cyclic depsipeptide
7. Pharmaceutical development of a parenteral lyophilized formulation of the novel antitumor agent aplidine
8. Current perspectives on pain upon injection of drugs
9. Effect of pH on injection phlebitis
10. Studies in phlebitis V: Hemolysis as a model for phlebitis
11. Lysis of human red blood cells 2: Effect of contact time on cosolvent induced hemolysis
12. Lysis of human red blood cells 4: Comparison of in vitro and in vivo hemolysis data
13. Lysis of human red blood cells 3: Effect of contact time on surfactant-induced hemolysis
14. In vitro biocompatibility studies with the experimental anticancer agent BIBX1382BS
15. Compatibility and stability of aplidine, a novel marine-derived depsipeptide antitumor agent, in infusion devices, and its hemolytic and precipitation potential upon i.v. administration
16. Precipitation of pH solubilized phenytoin