Determination of ketobemidone and its metabolites in plasma and urine using solid-phase extraction and liquid chromatography-mass spectrometry

Therapeutic Drug Monitoring

Volumn 23, Issue 4, 2001, Pages 399-405

  Svensson, Jan Olof ^a   Säwe, Juliette ^a   Al Shurbaji, Ayman ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Ketobemidone; LC MS; Metabolite

Indexed keywords

KETOBEMIDONE; NORKETOBEMIDONE; OPIATE AGONIST; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; RELIABILITY; SOLID PHASE EXTRACTION;

ANALGESICS, OPIOID; CHROMATOGRAPHY, LIQUID; HUMANS; MEPERIDINE; QUALITY CONTROL; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTANCE ABUSE DETECTION;

EID: 0034896906     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200108000-00013     Document Type: Article

References (4)

1. Quantitative determination of the urinary excretion of ketobemidone and four of its metabolites after intravenous and oral administration in man
2. Synthesis and mass spectra of deuterium-labelled ketobemidone and of some potential ketobemidone metabolites
3. Simultaneous determination of ketobemidone and its N-demethylated metabolite in patient plasma samples by gas chromatography mass spectrometry with selected ion monitoring
4. Validation of urine drug-of-abuse testing methods for ketobemidone using thin-layer chromatography and liquid chromatography-electrospray mass spectrometry