Potential role of Gab1 and phospholipase C-γ in osmotic shock-induced glucose uptake in 3T3-L1 adipocytes

Hormone and Metabolic Research

Volumn 33, Issue 7, 2001, Pages 402-406

  Ueno, E ^a   Haruta, T ^a   Uno, T ^a   Usui, I ^a   Iwata, M ^a   Takano, A ^a   Kawahara, J ^a   Sasaoka, T ^a   Ishibashi, O ^a   Kobayashi, M ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Adipocytes; Gab1; Glucose uptake; Osmotic shock; Phospholipase C

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; CYTOCHALASIN D; DEOXYGLUCOSE; GLUCOSE; PAXILLIN; PHOSPHOLIPASE C;

ACTIN POLYMERIZATION; ADIPOCYTE; ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; GLUCOSE TRANSPORT; MOUSE; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADIPOCYTES; ANIMALS; CYTOCHALASIN D; DEOXYGLUCOSE; GLUCOSE; IMMUNOBLOTTING; ISOENZYMES; MICE; NUCLEIC ACID SYNTHESIS INHIBITORS; OSMOTIC PRESSURE; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; TYROSINE;

ANIMALIA; CANIS FAMILIARIS;

EID: 0034896751     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-16227     Document Type: Article

References (16)

1. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane
2. Proc.: Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site
3. The insulin signaling system
4. Insulin action and the insulin signaling network
5. Signaling mechanisms that regulates glucose transport
6. Osmotic shock stimulates glut4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway
7. Ligand-independent glut4 translocation induced by guanosine 5′-O-(3-thiotriphosphate) involves tyrosine phosphorylation
8. Guanosine 5′-O-(3-thiotriphosphate) (GTPγS) stimulation of glut4 translocation is tyrosine kinase-dependent
9. Insulin-stimulated glut4 translocation is mediated by a divergent intracellular signaling pathway
10. Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane
11. Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
12. A Gab2-associated docking protein in EGF- and insulin-receptor signalling
13. Regulation of phosphoinositide-specific phospholipase C Isozymes
14. Role for phospholipase C activity in glut4-mediated glucose transport
15. Association of the insulin receptor with phospholipase Cγ-(PLCγ) in 3T3-L1 adipocytes suggests a role for PLC in metabolic signaling by insulin
16. The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by Gab-1 and requires Gab-1-associated phosphatidylinositol 3-kinase activity for full activation