The role of acetaldehyde in pregnancy outcome after prenatal alcohol exposure

Therapeutic Drug Monitoring

Volumn 23, Issue 4, 2001, Pages 427-434

  Hard, Marjie L ^a   Einarson, Thomas R ^a   Koren, Gideon ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Acetaldehyde; Epidemiology; Fetal alcohol syndrome; Incidence

Indexed keywords

ACETALDEHYDE;

ALCOHOLISM; ARTICLE; BIRTH DEFECT; CHILDBIRTH; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; FEMALE; FETAL ALCOHOL SYNDROME; HUMAN; INCIDENCE; MEDICAL INFORMATION; PREGNANCY COMPLICATION; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL;

ACETALDEHYDE; ALCOHOLISM; ETHANOL; FEMALE; FETAL ALCOHOL SYNDROME; HUMANS; INCIDENCE; INFANT, NEWBORN; MATERNAL-FETAL EXCHANGE; META-ANALYSIS; MULTIVARIATE ANALYSIS; PREGNANCY; PREGNANCY OUTCOME; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 0034896018     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200108000-00018     Document Type: Article

References (97)

1. An update on incidence of FAS: FAS is not an equal-opportunity birth defect
2. Perspectives on the cause and frequency of the fetal alcohol syndrome
3. Covalent binding of acetaldehyde selectively inhibits the catalytic activity of lysine-dependent enzymes
4. Functional consequences of acetaldehyde binding to proteins
5. Increased susceptibility of hepatic mitochondria to the toxicity of acetaldehyde after chronic ethanol consumption
6. The effect of acetaldehyde on mitochondrial function
7. Role of acetaldehyde in the pathogenesis of alcoholic liver disease
8. Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in the livers of rats with alcoholic liver disease
9. Effects of prenatal alcohol exposure in mice: Influence of an ADH inhibitor and a chronic inhalation study
10. An experimental study of fetal alcohol syndrome in the rat: Biochemical modifications in brain and liver
11. Mechanisms of fetal alcohol effects: Role of acetaldehyde
12. The role of maternal alcohol damage on ethanol teratogenicity in the rat
13. Potentiation of ethanol toxicity by cyanamide in relation to acetaldehyde accumulation
14. Teratogenic effects of acetaldehyde in the rat
15. Effect of acetaldehyde on skeletogenesis in rats
16. Elevated blood acetate as indicator of fast ethanol elimination in chronic alcoholics
17. Effect of the cytochrome P-450IIE1 genotype on ethanol elimination rate in alcoholics and control subjects
18. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism
19. Effects of fasting and chronic alcohol consumption on the first-pass metabolism of ethanol
20. Comparative study on ethanol elimination and blood acetaldehyde between alcoholics and control subjects
21. Blood acetaldehyde concentration gradient between hepatic and antecubital venous blood in ethanol-intoxicated alcoholics and controls
22. Impaired acetaldehyde oxidation in alcoholics
23. Changes in blood acetaldehyde levels after ethanol administration in alcoholics
24. Determinants of blood acetaldehyde level during ethanol oxidation in chronic alcoholics
25. Elevated blood acetaldehyde in alcoholics with accelerated ethanol elimination
26. The alcohol syndromes: The intrarecombigenic effect of acetaldehyde
27. Fetal abnormality and maternal ethanol metabolism
28. Hemoglobin-acetaldehyde adducts are elevated in women carrying alcohol-damaged fetuses
29. Pharmacoeconomic applications of meta-analysis for single groups using antifungal onychomycosis lacquers as an example
30. Blood ethanol and acetaldehyde levels in Japanese alcoholics and controls
31. Effect of abstinence on the blood acetaldehyde response to a test dose of alcohol in alcoholics
32. Blood acetaldehyde and ethanol levels in alcoholism
33. Effect of ethanol challenge on serum glycoproteins in alcoholic and nonalcoholic liver disease
34. Determination of free acetaldehyde in blood as the dinitrophenylhydrazone derivative by high-performance liquid chromatography
35. Elevated endogenous breath acetaldehyde levels among abusers of alcohol and cigarettes
36. Endogenous breath acetaldehyde levels among alcoholic and non-alcoholic probands: Effect of alcohol use and smoking
37. Lack of difference in blood acetaldehyde of alcoholics and controls after ethanol ingestion
38. Aldehyde oxidizing capacity of erythrocytes in normal and alcoholic individuals
39. Effects of liver disease on red blood cell acetaldehyde in alcoholics and non-alcoholics
40. Method of acetaldehyde measurement with minimal artifactual formation in red blood cells and plasma of actively drinking subjects with alcoholism
41. Red blood cells: A new major modality for acetaldehyde transport from liver to other tissues
42. Improved method for acetaldehyde in plasma and hemoglobin-associated acetaldehyde: Results in teetotalers and alcoholics reporting for treatment
43. Impaired acetaldehyde metabolism in patients with non-alcoholic liver disorders
44. Calcium carbimide-ethanol interaction
45. Divergence of ethanol and acetaldehyde kinetics and of the disulfiram-alcohol reaction between subjects with and without alcoholic liver disease
46. The calcium cyanamide-ethanol interaction in man. Effects of repeated ethanol administration
47. Distribution of acetaldehyde in human blood: Effects of ethanol and treatment with disulfiram
48. Determinanats of ethanol and acetaldehyde metabolism in chronic alcoholics
49. Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder
50. Fetal alcohol syndrome: A Japanese perspective
51. The prevalence of fetal alcohol syndrome in New Zealand
52. The prevalence of genetic disorders, birth defects and syndromes in central and eastern Kentucky
53. Incidence of fetal alcohol syndrome in northeastern Manitoba
54. Fetal alcohol syndrome in Saskatchewan: Unchanged incidence in a 20-year period
55. Surveillance for fetal alcohol syndrome in Colorado
56. Fetal alcohol syndrome at schools for mentally handicapped children in Concepcion, Chile
57. Use of capture-recapture analyses in fetal alcohol syndrome surveillance in Alaska
58. Fetal alcohol effects-incidence and understanding in the Cape
59. Fetal alcohol syndrome (FAS): New definition, new prospective sample, same etiology
60. A revised conservative estimate of the incidence of FAS and its economic impact
61. A comparison of the effects of prenatal exposure to tobacco, alcohol, cannabis and caffeine on birth size and subsequent growth
62. Maternal alcohol, tobacco and cannabis consumption and the outcome of pregnancy
63. Is there a fetal effect with low to moderate alcohol use before or during pregnancy?
64. Epidemiology of fetal alcohol syndrome among American Indians of the Southwest
65. A semiquantitative score system for epidemiologic studies of fetal alcohol syndrome
66. Effects of maternal drinking and marijuana use on fetal growth and development
67. Prenatal exposure to alcohol: Effect on infant growth and morphologic characteristics
68. Under-recognition of prenatal alcohol effects in infants of known alcohol-abusing women
69. Moderate alcohol use and pregnancy outcome
70. Alcohol and pregnancy: An international comparison
71. Cigarette smoking, alcohol consumption and fetal outcome in Tasmania 1981-82
72. The effect of moderate maternal alcohol consumption on birth weight and gestational age in a low-risk population
73. Alcohol consumption, pregnancy, and low birthweight
74. "J-shaped" relationship between drinking during pregnancy and birth weight: Reanalysis of prospective epidemiological data
75. Decreased birth weight in infants of alcoholic women who abstained during pregnancy
76. Intrauterine growth in infants born to women with alcohol-related psychiatric diagnoses
77. Significant determinants of susceptibility to alcohol teratogenicity
78. Outcome in offspring of chronic alcoholic women
79. Clinical profile and prevalence of fetal alcohol syndrome in an isolated community in British Columbia
80. Alcohol consumption during pregnancy and newborn outcome: A study in Brazil
81. Effects on the child of alcohol abuse during pregnancy. Retrospective and prospective studies
82. The effects of moderate alcohol consumption during pregnancy on fetal growth and morphogenesis
83. Dysmorphic features in offspring of alcoholic mothers
84. Prevention of fetal alcohol effects. An antenatal program for early detection of pregnancies at risk
85. Evaluation of serum gamma-glutamyl transferase as a screening method for excessive alcohol consumption during pregnancy
86. Alcohol counselling of 85 pregnant problem drinkers: Effect on drinking and fetal outcome
87. Alcohol use in pregnancy, craniofacial features, and fetal growth
88. Incidence of fetal alcohol syndrome on the southern part of Reunion Island (France)
89. Alcohol abuse during pregnancy: An epidemiologic study
90. Adverse effects on offspring of mammal alcohol abuse during pregnancy
91. Incidence of major congenital malformations in offspring of alcoholics and polydrug abusers
92. Human blood acetaldehyde concentration during ethanol oxidation (update 1982)
93. Human blood acetaldehyde (update 1992)
94. Elimination of artifactual acetaldehyde in the measurement of human blood acetaldehyde by the use of polyethylene glycol and sodium azide: Normal blood acetaldehyde levels in the dog and human after ethanol
95. Role of hepatic acetaldehyde dehydrogenase in alcoholism: Demonstration of persistent reduction of cytosolic activity in abstaining patients
96. Aldehyde dehydrogenase in alcoholic subjects
97. Fetal alcohol syndrome primary prevention through FAS diagnosis: I. Identification of high-risk birth mothers through the diagnosis of their children