Long-term treatment with enalapril or losartan does not show antiproliferative effects in peripheral blood mononuclear cells

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 23, Issue 3, 2001, Pages 149-152

  Petrov, V V ^a   Fagard, R H ^a   Lijnen, P J ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Enalapril; Losartan; Mononuclear cells; Peripheral blood; Proliferation

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DNA; ENALAPRIL; LEUCINE; LOSARTAN; PLACEBO; PROTEIN; RNA; THYMIDINE; TRITIUM; URIDINE;

ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DNA SYNTHESIS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENZYME INHIBITION; ESSENTIAL HYPERTENSION; HUMAN; HUMAN CELL; LONG TERM CARE; MALE; MONONUCLEAR CELL; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; RNA SYNTHESIS;

EID: 0034894758     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2001.23.3.627949     Document Type: Article

References (30)

1. Cellular mechanisms of captopril-induced matrix remodeling in syrian hamster cardiomyopathy
2. Induction of angiotensin I-converting enzyme by captopril in cultured human endothelial cells
3. Comparative study of ACE inhibitors and angiotensin II receptor antagonists in interstitial scarring
4. Captopril reduces collagen and mast cell and eosinophil accumulation in pig serum induced rat liver fibrosis
5. Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin 11 type I receptor blockade on cardiac remodeling after myocardial infarction in the rat
6. Connective tissue and repair in the heart. Potential regulatory mechanisms
7. Effects of enalaprilat on intimal growth of cultured rabbit aorta following ballon injury
8. Quinapril inhibits c-Myc expression and normalize smooth muscle cell proliferation in spontaneously hypertensive rats
9. Effects of early and late antihypertensive treatment on extracellular matrix proteins and mononuclear cells in uninephrectomized SHR
10. Angiotensin converting enzyme inhibition of the postnatal rat resalts results in decreased cell proliferation in the renal outer medulla
11. Pharmacologie suppression of intimal hyperplasia: A dose-response suppression by enalapril
12. Differential effects of angiotensin on cardiac cell proliferation and intramyocardial perivascular fibrosin in vivo
13. Angiotensin I-converting enzyme in human circulating mononuclear cells: Genetic polymorphism of expression in T-lymphocytes
14. Effect of converting enzyme inhibitor captopril on T-cell functions in essential hypertension
15. Captopril (SQ 14,225): In vitro and in vivo influence on the proliferative response of rat lymphocytes
16. A comparison of the effects of angiotensin-converting enzyme inhibitors with bradykinin, angiotensin II and their specific antagonists on concanavalin A-induced proliferation of mouse T-lymphocytes
17. Stimulatory effects of angiotensin II on the proliferation of mouse spleen lymphocytes in vitro is mediated via both types of angiotensin receptors
18. A randomised placebo-controlled double-blind cross-over study of losartan and enalapril in patients with essential hypertension
19. Effect of protease inhibitors angiotensin-converting enzyme activity in human T-lymphocytes
20. In vitro proliferative response of human peripheral blood mononuclear cells to concanavalin A
21. Proliferation of human peripheral blood mononuclear cells during calcium channel blockade
22. Influence of losartan, an angiotensin receptor antagonist, on neointimal proliferation in cultured human saphenous vein
23. Effects of sulphydryl and non-sulphydryl angiotensin converting enzyme inhibitors on mitogen-induced proliferation of mouse splenocytes
24. Rat angiotensin (type IA) receptor mRNA regulation and subtype, expression in myocardial growth attd hypertrophy
25. Kinins mediate the antiproliferative effect of ramipril in rat carotid artery
26. ACE inhibitor-mediated attenuation of mesangial cell growth. A role for endothelin
27. Ramipril inhibits in vitro human mesangial cells proliferation and platelet-derived growth factor expression
28. Effect of angiotensin blockade on the fibroproliferative response to phenylephrine in the rat heart
29. Macrophages and myofibrolast proliferation in remnant kidney: Role of angiotensin
30. T-lymphocyte and plasma angiotensin converting enzyme activity during enalapril and losartan administration in men