The kinetics of the alkaline degradation of daptomycin

Journal of Pharmaceutical Sciences

Volumn 90, Issue 8, 2001, Pages 1066-1075

  Muangsiri, Walaisiri ^a   Kirsch, Lee E ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Daptomycin; Drug stability; Ester hydrolysis; Lipopeptide antibiotic; Peptide degradation pathway; pH rate profile

Indexed keywords

BORIC ACID; CARBONIC ACID; DAPTOMYCIN; KYNURENINE; THREONINE;

ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; DRUG DEGRADATION; FLUORESCENCE SPECTROSCOPY; FOURIER ANALYSIS; HYDROLYSIS; IONIC STRENGTH; MASS SPECTROMETRY; REACTION ANALYSIS; TEMPERATURE SENSITIVITY;

EID: 0034892193     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1060     Document Type: Article

References (16)

1. Comparison of in vitro inhibitory and bactericidal activities of daptomycin (LY 146032) and four reference antibiotics, singly and in combination, against gentamicin-susceptible and high-level-gentamicin-resistant enterococci
2. Differential increased survival of staphylococci and limited ultrastructural changes in the core of infected fibrin clots after daptomycin administration
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5. Fluorescence indicates a calcium-dependent interaction between the lipopeptide antibiotic LY 146032 and phospholipid membranes
6. Poly(N-isopropylacrylamide) films at the air-water interface
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10. A dynamic light scattering study of β-galactosidase: Environmental effects on protein conformation and enzyme activity
11. Calcium binding to calmodulin and its globular domains