Highly increased CSF tau protein and decreased β-amyloid (1-42) in sporadic CJD: A discrimination from Alzheimer's disease?

Journal of Neurology Neurosurgery and Psychiatry

Volumn 71, Issue 3, 2001, Pages 401-403

  Kapaki, E ^a   Kilidireas, K ^a   Paraskevas, G P ^a   Michalopoulou, M ^a   Patsouris, E ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Alzheimer's disease; Creutzfeldt Jakob disease; Tau protein; amyloid 1 42

Indexed keywords

AMYLOID BETA PROTEIN; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DIFFERENTIAL DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; ONSET AGE; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL;

EID: 0034892016     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.71.3.401     Document Type: Article

References (14)

1. Zeidler M, Gibbs C, Meslin F. WHO Manual for strengthening diagnosis and surveillance of Creutzfeldt-Jakob disease 1998:7-8, 47-51.
2. Vandermeeren M, Mercken M, Vanmechelen E, et al. Detection of τ proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzymelinked immunosorbent assay. J Neurochem 1993;61:1828-34.
3. 42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol 1995;38:643-8.
4. Hulstaert F, Blennow K, Ivanoiu A, et al. Improved discrimination of AD pateints using β-Amyloid (1-42) and tau levels in CSF. Neurology 1999;52:1555-62.
5. Hainfellner JA, Wanschitz J, Jellinger K, et al. Coexistence of Alzheimer-type neuropathology in Creutzfeldt-Jakob disease. Acta Neuropathol 1998;96:116-22.
6. Barcikowska M, Kwiecinski H, Liberski PP, et al. Creutzfeldt-Jakob disease with Alzheimer-type A beta-reactive amyloid plaques. Histopathology 1995;26:445-50.
7. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease. Report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-44.
8. Otto M, Wiltfang J, Tumani H, et al. Elevated levels of tauprotein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neurosci Lett 1997;225:210-12.
9. 1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neurology 2000;54:1099-102.
10. Kanemaru K, Kameda N, Yamanouchi H. Decreased CSF amyloid β42 and normal tau levels in dementia with Lewy bodies. Neurology 2000;54:1875-6.
11. Tapiola T, Overmyer M, Lehtovirta M, et al. The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer's disease. Neuroreport 1977;8:3961-3.
12. Kapaki E, Paraskevas GP, Michalopoulou M, et al. CSF tau is increased in multiple sclerosis. Eur Neurol 2000;43:228-32.
13. Small DH, McLean CA. Alzheimer's disease and the amyloid β protein: what is the role of amyloid? J Neurochem 1999;73:443-9.
14. Zerr I, Bodemer M, Gefeller O, et al. Detection of 14-3-3 protein in the CSF supports the diagnosis of Creutzfeldt-Jakob disease. Ann Neurol 1998;43:32-40.