Do ΔF508 heterozygotes have a selective advantage?

Genetical Research

Volumn 78, Issue 1, 2001, Pages 41-47

  Wiuf, C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DEMOGRAPHY; EUROPE; GENE FREQUENCY; GENE LOCUS; GENETIC ANALYSIS; GENETIC SELECTION; HETEROZYGOTE; HISTORY; HUMAN; MUTATION; POPULATION;

CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EVOLUTION; HETEROZYGOTE; HUMANS; MICROSATELLITE REPEATS; MODELS, GENETIC; MUTATION; TIME FACTORS;

EID: 0034891467     PISSN: 00166723     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0016672301005195     Document Type: Article

References (18)

1. Cystic fibrosis
2. The Genetics of Human Populations
3. Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model
4. Age of the ΔF508 cystic fibrosis mutation
5. Identification of the cystic fibrosis gene: Genetic analysis
6. Detection of five novel mutations of the Cystic Fibrosis Transmembrane Regulator (CFTR) gene in Pakastani patients with cystic fibrosis: Y569D, Q98X, 296 + 12(T > C), 1161delC and 621 + 2(T > C)
7. The age of a rare mutant gene in a large population
8. The origin of the major cystic fibrosis mutation (ΔF508) in European populations
9. The cystic fibrosis heterozygote: Advantage in surviving cholera?
10. On the genealogy of nested subsamples from a haploid population
11. Protection against bronchial-asthma by CFTR ΔF508 mutation: A heterozygote advantage in cystic fibrosis
12. Studies of RFLP closely linked to the cystic fibrosis locus throughout Europe lead to new considerations in population genetics
13. Estimating the age of alleles by use of intraallelic variability
14. Inferring coalescence times from DNA sequence data
15. Mutations and sequence variations detected in the cystic fibrosis conductance regulator (CFTR) gene: A report from the Cystic Fibrosis Genetic Analysis Consortium
16. On the genealogy of a sample of neutral rare alleles
17. Rare alleles and selection
18. Conditional genealogies and the age of a neutral mutant