A common inhibitory binding site for zinc and odorants at the voltage-gated K+ channel of rat olfactory receptor neurons

European Journal of Neuroscience

Volumn 14, Issue 2, 2001, Pages 353-362

  Seebungkert, B ^a   Lynch, J W ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Cysteine; Diethylpyrocarbonate; Histidine; Metal binding site; Nitric oxide; Olfactory transduction

Indexed keywords

ACETOPHENONE; DIETHYL PYROCARBONATE; HISTIDINE; PENTYL ACETATE; POTASSIUM CHANNEL; POTASSIUM ION;

ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; COMPETITIVE INHIBITION; CONTROLLED STUDY; DEPOLARIZATION; KINETICS; NONHUMAN; ODOR; OLFACTORY RECEPTOR; PH; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SIGNAL TRANSDUCTION;

4-CHLOROMERCURIBENZENESULFONATE; ACETOPHENONES; ANIMALS; BINDING SITES; CARBON MONOXIDE; CELLS, CULTURED; CYCLOHEXENES; CYSTEINE; DIETHYL PYROCARBONATE; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTIDINE; MEMBRANE POTENTIALS; MESYLATES; NEURAL INHIBITION; NITRIC OXIDE; OLFACTORY RECEPTOR NEURONS; PATCH-CLAMP TECHNIQUES; PENTANOLS; POTASSIUM; POTASSIUM CHANNELS; RATS; RECEPTORS, ODORANT; SMELL; SULFHYDRYL REAGENTS; TERPENES; ZINC;

EID: 0034891216     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01646.x     Document Type: Article

References (47)

1. Liquid junction potentials and small cell effects in patch-clamp analysis
2. + channel are not essential for channel activity or zinc modulation
3. Implications of the NO/cGMP system for olfaction
4. A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
5. + channels
6. Chemosensory responses in isolated olfactory receptor neurons from Necturus maculosus
7. +, and nonselective cation conductances by taurine in olfactory receptor neurons of the mudpuppy, necturus maculosis
8. Action potentials and chemosensitive conductances in the dendrites of olfactory neurons suggest new features for odor transduction
9. Single unit recording from olfactory cilia
10. Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels
11. Divalent cations and the activation kinetics of potassium channels in squid giant axons
12. 2+
13. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein
14. Direct demonstration of a physiological role for carbon monoxide in olfactory receptor neurons
15. Substituted-cysteine accessibility method
16. Odorant suppression of delayed rectifier potassium current in newt olfactory receptor cells
17. Nonselective suppression of voltage-gated currents by odorants in the newt olfactory receptor cells
18. Adrenaline enhances odorant contrast by modulating signal encoding in olfactory receptor cells
19. Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells
20. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
21. + conductance in rat olfactory neurons
22. The spatial distribution of odorant sensitivity and odorant-induced currents in salamander olfactory receptor cells
23. Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells
24. Modification of histidine residues
25. Nitric oxide inhibition of the rat olfactory cyclic nucleotide-gated cation channel
26. + channels in rat olfactory receptor neurons
27. + channels in rat olfactory receptor neurons
28. Quantal-like current fluctuations induced by odorants in olfactory receptor cells
29. Evidence for an essential histidine residue located in the binding site of the cysteine-specific lysosomal transport protein
30. + channels: Subunit selective antagonism by zinc
31. Electrotonic structure of olfactory sensory neurons analyzed by intracellular and whole cell patch techniques
32. Adaptation of the odour-induced response in frog olfactory receptor cells
33. Characterization of the total lipid and fatty acid composition of rat olfactory mucosa
34. Odor suppression of voltage-gated currents contributes to the odor-induced response in olfactory neurons
35. Excitation, inhibition, and suppression by odors in isolated toad and rat olfactory receptor neurons
36. Transduction mechanisms in vertebrate olfactory receptor cells
37. Discrimination of molecular signals by the olfactory receptor neuron
38. Modification of potassium kinetics by histidine-specific reagents
39. Modification of potassium kinetics by amino group reagents
40. Chemical properties of the divalent cation binding site on potassium channels
41. Modulation of potassium channel gating by external cations
42. Voltage-independent gating transitions in squid axon potassium channels
43. Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates
44. A spectroscopic mechanism for primary olfactory reception
45. a channels by carbon monoxide in vascular smooth muscle cells
46. The moving parts of voltage-gated ion channels
47. A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2