Lethality-based selection of recombinant genes in mammalian cells: Application to identifying tumor antigens

Nature Medicine

Volumn 7, Issue 8, 2001, Pages 967-972

  Smith, Ernest S ^a,b   Mandokhot, Aparna ^a,b   Evans, Elizabeth E ^a,b   Mueller, Loretta ^a   Borrello, Melinda A ^a   Sahasrabudhe, Deepak M ^a,b   Zauderer, Maurice ^a,b  

^a VACCINEX INC   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR ANTIGEN; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DNA LIBRARY; GROWTH DISORDER; IMMUNOTHERAPY; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECOMBINANT GENE; VACCINIA VIRUS; VIRUS TITRATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NEOPLASM; BASE SEQUENCE; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; GENES, LETHAL; GENETIC VECTORS; MICE; MICE, INBRED BALB C; RECOMBINANT PROTEINS; RIBOSOMAL PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VACCINIA VIRUS;

EID: 0034890610     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/91017     Document Type: Article

References (22)

1. The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice
2. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
3. The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
4. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor
5. Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection
6. BAGE: A new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes
7. Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma
8. Shared T cell defined antigens on independently derived tumors
9. In vivo surveillance of tumorigenic cells transformed in vitro
10. Analysis of immune surveillance of sequentially derived cell lines that differ in their tumorigenic potential
11. Vaccinia virus: A tool for research and vaccine development
12. Poxvirus expression vectors
13. Construction and characterization of vaccinia direct ligation vectors
14. Fowlpox virus host range restriction: Gene expression, DNA replication, and morphogenesis in nonpermissive mammalian cells
15. Retrovirus activation in embryonal carcinoma cells by cellular promoters
16. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains
17. The primary structure of rat ribosomal protein L3
18. cDNA sequence for bovine ribosomal protein L3 carrying a bipartite nuclear targeting motif, identified also in many other ribosomal proteins
19. + T lymphocytes
20. Endogenous myelin basic protein inactivates the high avidity T cell repertoire
21. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein
22. Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase