Serum TIMP-1, TIMP-2, and MMP-1 in patients with systemic sclerosis, primary Raynaud's phenomenon, and in normal controls

Annals of the Rheumatic Diseases

Volumn 60, Issue 9, 2001, Pages 846-851

  Young Min, S A ^a   Beeton, C ^b   Laughton, R ^a   Plumpton, T ^b   Bartram, S ^c   Murphy, G ^d   Black, C ^e   Cawston, T E ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^e ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERSTITIAL COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE COURSE; DISEASE SEVERITY; ENZYME BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAYNAUD PHENOMENON; SERUM; SYSTEMIC SCLEROSIS;

ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASE 1; MIDDLE AGED; RAYNAUD DISEASE; SCLERODERMA, SYSTEMIC; STATISTICS, NONPARAMETRIC; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 0034890197     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Activation of tissue inhibitor of metalloproteinases-3 (TIMP-3) mRNA expression in scleroderma skin fibroblasts
2. Control of fibrosis in systemic scleroderma
3. Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis
4. Scleroderma and related disorders in adults and children
5. Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization
6. Scleroderma: Increased biosynthesis of triple-helical type I and type III procollagens associated with unaltered expression of collagenase by skin fibroblasts in culture
7. Gene expression of types I and III collagen, decorin, matrix metalloproteinases and tissue inhibitors of metalloproteinases in skin fibroblasts from patients with systemic sclerosis
8. Decreased collagenase expression in cultured systemic sclerosis fibroblasts
9. Excess matrix accumulation in scleroderma is caused partly by differential regulation of stromelysin and TIMP-1 synthesis
10. Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1
11. Tissue inhibitor of metalloproteinase 1 (TIMP-1) may be an autocrine growth factor in scleroderma fibroblasts
12. Serum levels of tissue inhibitor of metalloproteinases 2 in patients with systemic sclerosis
13. Preliminary criteria for the classification of systemic sclerosis (scleroderma)
14. Systemic sclerosis (scleroderma) and related disorders
15. Development of an enzyme-linked immunosorbent assay to measure total TIMP-1 (free TIMP-1 and TIMP-1 in combination with matrix-metalloproteinases) and measurement of TIMP-1 and CRP in serum
16. Monoclonal antibodies against human fibroblast collagenase and the design of an enzyme-linked immunosorbent assay to measure total collagenase
17. Serum tissue inhibitor of metalloproteinases in patients with systemic sclerosis
18. Serum levels of collagenase, stromelysin-1, and TIMP-1. Age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of anti-genic keratan sulfate in patients with osteoarthritis