Comparison of protease genotype and phenotype in HIV-1 infected patients exposed to more than one protease inhibitor

Journal of Biological Regulators and Homeostatic Agents

Volumn 15, Issue 2, 2001, Pages 166-169

  Gianotti, N ^a   Tambussi, G ^a   Boeri, E ^a   Lazzarin, A ^a  

^a Divisione di Malattie Infettive   (Italy)

Author keywords

Antiretroviral therapy; Genotype; HIV; Phenotype; Protease inhibitors; Resistance

Indexed keywords

INDINAVIR; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR;

ANTIBIOTIC RESISTANCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONOTHERAPY; MUTATION; PHENOTYPE; TREATMENT FAILURE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034889716     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Resistance to human immunodeficiency virus type 1 protease inhibitors
2. Resistance table. Mutations in retroviral genes associated with drug resistance: 1999-2000 update
3. Antiviral and resistance studies of AG1343, on orally bioavailable inhibitor of Human Immunodeficiency Virus protease
4. Impact of drug resistance mutations on virologic response to salvage therapy
5. Relationship of baseline viral phenotype and genotype to RNA response atter switching from long-term saquinavir to indinavir or saquinavir soft-gelatin capsule in ACTG 333
6. Efficacy of a five-drug combination including ritonavir, saquinavir and efavirenz in patients who failed on a conventional triple-drug regimen: Phenotypic resistance to protease inhibitors predict outcome of therapy
7. Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy
8. Genotypic correlates of reduced in vitro susceptibility to ABT-378 in HIV isolates from patients failing protease inhibitor therapy
9. Site-directed mutagenesis and in vitro drug selection studies have failed to reveal a consistent genotypic resistance pattern for tipranavir
10. Virologic Clinical Reference Laboratory. Discordance between genotype-based predictions of protease inhibitor susceptibility and actual phenotype in HIV-1 isolates containing mutations at positions 82 mutations at positions 46 and 54