Plasma pharmacokinetics and bioavailability of 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea after intravenous and oral administration to mice and dogs

Cancer Chemotherapy and Pharmacology

Volumn 48, Issue 3, 2001, Pages 202-208

  Supko, J G ^a   Garcia Carbonero, R ^a   Puchalski, T A ^a   Malspeis, L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Antineoplastic agents; Nitrosoureas; Pharmacokinetics; Preclinical studies

Indexed keywords

1 (2 CHLOROETHYL) 3 SARCOSINAMIDE 1 NITROSOUREA; CHLOROETHYLNITROSOUREA; NITROSOUREA DERIVATIVE; NSC 364432; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; COLONY FORMING UNIT; CONTROLLED STUDY; DOG; DRUG DISPOSITION; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PLASMA CLEARANCE; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; STOMACH INTUBATION;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CARMUSTINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; INFUSIONS, INTRAVENOUS; MALE; MAXIMUM TOLERATED DOSE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; PROTEIN BINDING; PROTEINS;

EID: 0034888638     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800100326     Document Type: Article

References (26)

1. Mechanism of uptake of nitrosoureas by L5178Y lymphoblasts in vitro
2. Oral bioavailability and plasma elimination kinetics of (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarCNU) in the rat and dog
3. Glioma and medulloblastoma xenografts as models for brain tumor drug development
4. Chemotherapy of gliomas
5. Uptake and decomposition of chlorozotocin in L5178Y lymphoblasts in vitro
6. Comparison of the transport of chlorozotocin and CCNU in L1210 leukemia and murine bone marrow cells in vitro
7. Pharmacokinetics of BCNU in man: A preliminary study of 20 patients
8. 2-Chloroethyl-3-sarcosinamide-1-nitrosourea, a novel chloroethylnitrosourea analogue with enhanced antitumor activity against human glioma xenografts
9. The jacknife - A review
10. 11C-labelled BCNU and SarCNU in gliomas studied by PET
11. Preparation of mean drug concentration-time curves in plasma. A study on the frequency distribution of pharmacokinetic parameters
12. Transport of (2-chloroethyl)-3-sarcosinamide-1-nitrosourea in the human glioma cell line SK-MG-1 is mediated by an epinephrine-sensitive carrier system
13. Utilization of the HTSCA and CFU-C assay to identify two new 2-chloroethylnitrosourea congeners of amino acid amides with increased in vitro activity against human glioma compared with BCNU
14. Dimethyl sulfoxide: Its steroid solubility and endocrinologic and pharmacologic-toxicologic characteristics
15. The extraneuronal monoamine transporter exists in human central nervous system glia
16. The cytotoxicity of sarcosinamide chloroethylnitrosourea (SarCNU) and BCNU in primary gliomas and glioma cell lines: Analysis of data in reference to theoretical peak plasma concentrations in man
17. The cytotoxicity of a 2-chloroethylnitrosourea analog of sarcosinamide in the SK-MG-1 human glioma cell line as a possible indicator for transport
18. Transport of amino acid amide sarcosinamide and sarcosinamide chloroethylnitrosourea in human glioma SK-MG-1 cells
19. Comparative study on the influence of two 2-chloroethylnitrosoureas with different carbamoylating potential towards glutathione and glutathione-related enzymes in different organs of the rat
20. (2-Chloroethyl)nitrosourea congeners of amino acid amides
21. Specific high-performance liquid chromatographic assay with ultraviolet detection for the determination of 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea in plasma
22. Antitumor alkylating agents
23. Alkylating agents
24. Chloroethylnitrosourea cancer chemotherapeutic agents
25. A toxilogical study of dimethyl sulfoxide