Solid-state trans-cis isomerization of captopril determined by thermal fourier transform infrared (FT-IR) microspectroscopy

Journal of Pharmaceutical Sciences

Volumn 90, Issue 8, 2001, Pages 1034-1039

  Wang, Shun Li ^a   Lin, Shan Yang ^a   Chen, Ting Fang ^a   Chuang, Chi Hsiang ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Captopril; Cis trans isomerization; DSC; Solid state; Thermal FT IR

Indexed keywords

CAPTOPRIL; CARBOXYLIC ACID;

ARTICLE; HYDROGEN BOND; INFRARED SPECTROSCOPY; ISOMERISM; MELTING POINT; SOLID STATE; TEMPERATURE SENSITIVITY; THERMODYNAMICS;

EID: 0034888567     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1056     Document Type: Article

References (17)

1. Design of specific inhibitors of angiotensin-converting enzyme new class of orally active antihypertensive agents
2. Design of angiotension converting enzyme inhibitors
3. Conformationally restricted inhibitors of angiotensin converting enzyme: Synthesis and computations
4. Determination of the barrier to C-N bond rotation in captopril: Application of reference deconvolution to line-shape analysis
5. Conformational and acid-base equilibria of captopril in aqueous solution
6. Consideration of the possibility that the slow step in protein denaturation reactions is due to cistrans isomerism of proline residues
7. Kinetics and thermodynamics of cis-trans isomerization of captopril and related compounds
8. Thermal stability of methacrylic acid copolymers of eudragits L, S and L 30 D and the acrylic acid polymer of carbopol
9. Isothermal FT-IR micro-spectrosopic studies on the stability kinetics of solid-state intramolecular cyclization of aspartame sweetener
10. Thermal-dependent dehydration process and intramolecular cyclization of lisinopril dihydrate in the solid state
11. Nuclear magnetic resonance studies of the acid-base chemistry of amino acids and peptides. II. Dependence of the acidity of the c-terminal carboxyl group on the conformation of the c-terminal peptide bond
12. Infrared spectroscopy and structural chemistry. I. Keto-lactol tautomerism
13. SQ 14225: 1-(D-3-Mercapto-2-methylpropionyl)-L-proline
14. Conformational analysis and active siter modelling of angiotensin-converting enzyme inhibitors
15. Theoretical studies on cis-amide perference in N-methylanilides