Pharmacokinetics of orbifloxacin and its concentration in body fluids and in endometrial tissues of mares

Canadian Journal of Veterinary Research

Volumn 65, Issue 3, 2001, Pages 181-187

  Haines, Gregory R ^a   Brown, Murray P ^a   Gronwall, Ronald R ^a   Merritt, Kelly A ^a   Baltzley, Lance K ^a  

^a University of Florida College of Veterinary Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ORBIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ACTINOBACILLUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SYNOVIAL FLUID LEVEL; DRUG URINE LEVEL; ENDOMETRIUM; ESCHERICHIA COLI; FEMALE; HORSE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PASTEURELLA; PERITONEAL FLUID; SALMONELLA;

ANIMALS; AREA UNDER CURVE; ASCITIC FLUID; BACTERIA; BODY FLUIDS; CIPROFLOXACIN; ENDOMETRIUM; FEMALE; HALF-LIFE; HORSES; INTESTINAL ABSORPTION; MICROBIAL SENSITIVITY TESTS; SYNOVIAL FLUID; TISSUE DISTRIBUTION;

ACTINOBACILLUS; ACTINOBACILLUS EQUULI; ANIMALIA; EQUIDAE; EQUUS CABALLUS; ESCHERICHIA COLI; NEGIBACTERIA; PASTEURELLA; POSIBACTERIA; SALMONELLA;

EID: 0034886223     PISSN: 08309000     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Prescott JF, Baggot JD. Fluoroquinolones. In: Prescott JF, Baggot JD, eds. Antimicrobial Therapy in Veterinary Medicine. Ames: Iowa State University Press, 1993:252-262.
2. Hooper DC, Wolfson JS. Fluoroquinolone antibacterial agents. N Engl J Med 1991;324:384-394.
3. Giguère S, Sweeney RW, Bélanger M. Pharmacokinetics of enrofloxacin in adult horses and concentration of the drug in serum, body fluids, and endometrial tissues after repeated intragastrically administered doses. Am J Vet Res 1996;57: 1025-1030.
4. Orsini JA, Perkons S. The fluoroquinolones: clinical applications in veterinary medicine. Compend Contin Educ Pract Vet 1992; 14:1491-1496.
5. Vancutsem PM, Babish JG, Schwark WS. The fluoroquinolone antimicrobials: structure, antimicrobial activity, pharmacokinetics, clinical use in domestic animals and toxicity. Cornell Vet 1990;80:173-186.
6. Bahri LE, Blouin A. Fluoroquinolones: a new family of antimicrobials. Compend Contin Educ Pract Vet 1991;13:1429-1433.
7. Moore RM, Schneider RK, Kowalski J, Bramlage LR, Mecklenburg LM, Kohn CW. Antimicrobial susceptibility of bacterial isolates from 233 horses with musculoskeletal infection during 1979-1989. Equine Vet J 1992;24:450-456.
8. Sweeney CR, Holcombe SJ, Barningham SC, Beech J. Aerobic and anaerobic bacterial isolates from horses with pneumonia or pleuropneumonia and antimicrobial susceptibility pattern of the aerobes. J Am Vet Med Assoc 1991;198:839-842.
9. Hawkins JF, Bowman KF, Roberts MC, Cowen P. Peritonitis in horses: 67 cases (1985-1990). J Am Vet Med Assoc 1993;203: 284-288.
10. Asbury AC, Lyle SK. Infectious causes of infertility. In: McKinnon AO, Voss JL, eds. Equine Reproduction. Philadelphia: Lea &Febiger, 1993:381-391.
11. Johnston JK, Divers TJ, Reef VB, Acland H. Cholelithiasis in horses: ten cases (1982-1986). J Am Vet Med Assoc 1989;194: 405-409.
12. Burkhardt JE, Hill MA, Turek JJ, Carlton WW. Ultrastructural changes in articular cartilage of immature beagle dogs dosed with difloxacin, a fluoroquinolone. Vet Pathol 1992;29:230-238.
13. Burkhardt JE, Hill MA, Carleton WW, Kesterson JW. Histologic and histochemical changes in articular cartilage of immature beagle dogs dosed with difloxacin. Toxicol Pathol 1990;27:162-170.
14. Burkhardt JE, Hill MA, Carleton WW. Morphologic and biochemical changes in articular cartilage of immature beagle dogs dosed with difloxacin. Toxicol Pathol 1992;20:246-252.
15. Gough AW, Kasali OB, Sigler RE, Baragi V. Quinolone arthropathy - acute toxicity to immature articular cartilage. Toxicol Pathol 1992;20:436-449.
16. Stahlman R, Forster C, Shakibaei M, Vormann J, Gunther T, Merker HJ. Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy. Antimicrob Agents Chemother 1995;39:2013-2018.
17. Takada S, Kato M, Takayama S. Comparison of lesions induced by intra-articular injections of quinolones and compounds damaging cartilage components in rat femoral condyles. J Toxicol Environ Health 1994;42:73-88.
18. Bostian A, Vivrette SL, Bermingham E, Papich MG. Quinolone-induced arthropathy in neonatal foals. Proc Annu Meet Coll Vet Intern Med 1998:723.
19. Bermingham EC, Papich MG, Vivrette SL. Pharmacokinetics of enrofloxacin administered intravenously and orally to foals. Am J Vet Res 2000;61:706-709.
20. Bertone AL, Tremaine WH, Macoris DG, Simmons EJ, Ewart KM, Herr LG, Weisbrode SE. Effect of long-term administration of an injectable enrofloxacin solution on physical and musculoskeletal variables in adult horses. J Am Vet Med Assoc 2000;217: 1514-1520.
21. Norrby SR. Side effects of quinolones: comparisons between quinolones and other antibiotics. Eur J Clin Microbiol Infect Dis 1991;10:378-383.
22. Nakamura S. Veterinary use of new quinolones in Japan. Drugs 1995;49 Suppl 2:152-158.
23. Hamana M, Sekine F, Miyahara M. Therapeutic efficacy of orbifloxacin (AT-4526), a new injectable quinolone, in neonatal diarrhoea in piglets. Toho J Vet Clin 1994;17:1,8-16.
24. Brown MP, Gronwall RR, Houston AE. Pharmacokinetics and body fluid and endometrial concentrations of ormetoprim -sulfadimethoxine in mares. Can J Vet Res 1989;53:12-16.
25. Bennett JV, Brodie JL, Benner EJ, Kirby WM. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol 1966;14:170-177.
26. Caceci MS, Cacheris WP. Fitting curves to data. Byte 1984;9:340-362.
27. Gibaldi M, Perrier D. Pharmacokinetics. New York: Marcel Dekker, 1982:409-417.
28. Curry SH. Drug Disposition and Pharmacokinetics. Boston: Blackwell Scientific Publications, 1980:201-204.
29. Dowling PM, Wilson RC, Tyler JW, Duran SH. Pharmacokinetics of ciprofloxacin in ponies. J Vet Pharmacol Therap 1995;18:7-12.
30. Sullivan MC, Cooper BW, Nightingale CH, Quintiliani R, Lawlor MT. Evaluation of the efficacy of ciprofloxacin against Streptococcus pneumoniae by using a mouse protection model. Antimicrob Agents Chemother 1993;37:234-239.
31. Drusano GL, Johnson DE, Rosen M, Standiford HC. Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis. Antimicrob Agents Chemother 1993;37:483-490.
32. Kang SL, Rybak MJ, McGrath BJ, Kaatz GW, Seo SM. Pharmacodynamics of levofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with rifampin, against methicillin-susceptible and -resistant Staphylococcus aureus in an in vitro infection model. Antimicrob Agents Chemother 1994;38:2702-2709.
33. Ingerman MJ, Pitsakis PG, Rosenberg AF, Levison ME. The importance of pharmacodynamics in determining the dosing interval in therapy for experimental Pseudomonas endocarditis in the rat. J Infect Dis 1986;153:707-714.
34. Vogelman B, Gudmundsson G, Leggett J, Turnidge J, Ebert S, Craig WA. Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model. J Infect Dis 1988;158:831-847.
35. Forrest A, Nix DE, Ballow CH, Goss TF, Birmingham MC, Schentag JJ. Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients. Antimicrob Agents Chemother 1993;37:1073-1081.
36. Meinen JB, McClure JT, Rosen E. Pharmacokinetics of enrofloxacin in clinically normal dogs and mice and drug pharmacodynamics in neutropenic mice with Escherichia coli and staphylococcal infections. Am J Vet Res 1995;56:1219-1224.
37. Schneider RK, Bramlage LR, Moore RM, Mecklenburg LM, Kohn CW, Gabel AA. A retrospective study of 192 horses affected with septic arthritis/tenosynovitis. Equine Vet J 1992;24:436-442.
38. Langston VC, Sedrish S, Boothe DM. Disposition of single-dose oral enrofloxacin in the horse. J Vet Pharmacol Therap 1997;19:316-319.
39. Haines GR, Brown MP, Gronwall RR, Merritt KA. Serum concentrations and pharmacokinetics of enrofloxacin after intravenous and intragastric administration to mares. Can J Vet Res 2000;64:171-177.
40. Zehl U. Beitrag zur Pharmakokinetik des neuen Gyrasehemmers Baytril (enrofloxacin) beim Pferd (thesis). Durch die Tierärztliche Hochschule Hannover, 1989:87.