Combination of miglitol, an anti-diabetic drug, and nicorandil markedly reduces myocardial infarct size through opening the mitochondrial KATP channels in rabbits

British Journal of Pharmacology

Volumn 133, Issue 7, 2001, Pages 1041-1046

  Minatoguchi, S ^a   Wang, N ^a   Uno, Y ^a   Arai, M ^a   Hashimoto, K ^a   Hashimoto, Y ^a   Chen, X H ^a   Takemura, G ^a   Fujiwara, H ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Ischaemia; Miglitol; Myocardial infarction; Nicorandil; glucosidase inhibitor

Indexed keywords

MIGLITOL; NICORANDIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; HEART INFARCTION; HEART INFARCTION SIZE; HEMODYNAMICS; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0034883591     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704166     Document Type: Article

References (15)

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2. N-methyl-1-deoxynojirimycin (MOR-14), an α-glucosidase inhibitor, markedly reduced infarct size in rabbit hearts
3. The antiglycogenolytic action of 1-deoxynojirimycin results from a specific inhibition of the α-1,6-glucosidase activity of the debranching enzyme
4. Early phase acute myocardial infarct size quantification: Validation of the triphenyl tetrazolium chloride tissue enzyme staining technique
5. Transient ischemia in the presence of an adenosine deaminase plus a nucleoside transport inhibitor confers protection against contractile depression produced by hydrogen peroxide
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8. A novel anti-diabetic drug, miglitol, markedly reduces myocardial infarct size in rabbits
9. Role of glycolytic products in damage to ischemic myocardium: Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts
10. ATP channel in rabbits
11. Effect of 8-wk α-glucosidase inhibition on metabolic control, c-peptide secretion, hepatic glucose output, and peripheral insulin sensitivity in poorly controlled type II diabetic patients
12. Miglitol, a review of its therapeutic potential in type 2 diabetes mellitus
13. Determination of buffering capacity of rat myocardium during ischemia
14. Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment
15. Inhibition of intestinal α-glucosidase activity and post-grandial hyperglycemia by moranoline and its N-alkyl derivatives