Analysis of responses to hAmylin, hCGRP, and hADM in isolated resistance arteries from the mesenteric vascular bed of the rat

Peptides

Volumn 22, Issue 9, 2001, Pages 1427-1434

  Champion, Hunter C ^a   Pierce, Robert L ^a   Bivalacqua, Trinity J ^a   Murphy, William A ^a   Coy, David H ^a   Kadowitz, Philip J ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenomedullin; Amylin; Calcitonin gene related peptide; CGRP1 receptor; Mesenteric vascular bed; Vasodilator responses

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADRENOMEDULLIN; AMYLIN; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CYCLIC GMP; GUANYLATE CYCLASE INHIBITOR; N (1 ADAMANTYL) N' CYCLOHEXYL 4 MORPHOLINECARBOXAMIDINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; RECEPTOR PROTEIN;

ANALYTIC METHOD; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DATA ANALYSIS; HUMAN; MESENTERY BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; RAT; RESISTANCE BLOOD VESSEL; VASCULAR ENDOTHELIUM; VASODILATATION;

ACETYLCHOLINE; ADAMANTANE; ADRENOMEDULLIN; AMYLOID; ANIMALS; ARGININE; CALCITONIN GENE-RELATED PEPTIDE; CROMAKALIM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; MESENTERIC ARTERIES; MORPHOLINES; NITRIC OXIDE SYNTHASE; OXADIAZOLES; PEPTIDE FRAGMENTS; PEPTIDES; PERFUSION; POTASSIUM CHANNEL BLOCKERS; QUINOXALINES; RATS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RECEPTORS, PEPTIDE; VASCULAR RESISTANCE; VASODILATOR AGENTS;

EID: 0034882965     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(01)00482-X     Document Type: Article

References (30)

1. The demonstration of vasodilator activity of pancreatic amylin amide in the rabbit
2. Amylin influences insulin-stimulated glucose metabolism by two independent mechanisms
3. 2-terminal 20 peptide in the hindquarters vascular bed of the rat
4. 2-terminal 20 peptides has cAMP-mediated vasodilator activity in the mesenteric vascular bed of the cat
5. 2-terminal 20 peptide has direct vasodilator activity in the cat
6. Adrenomedullin-(22-52) antagonizes vasodilator responses to calcitonin gene-related peptide but not adrenomedullin in the cat
7. 1 receptors
8. A rat skeletal muscle cell line (L6) expresses specific adrenomedullin binding sites but activates adenylate cyclase via calcitonin gene-related peptide receptors
9. Amylin activates glycogen phosphorylase and inactivates glycogen synthase via a cAMP-independent mechanism
10. Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the pulmonary vascular bed of the cat
11. Stimulation of adenylate cyclase by amylin in CHO-K1 cells
12. 1 receptors
13. L-NAME modulates responses to adrenomedullin in the hindquarters vascular bed of the rat
14. Analysis of responses to adrenomedullin-(13-52) in the pulmonary vascular bed of the rat
15. The interaction of CGRP and adrenomedullin with a receptor expressed in the rat pulmonary vascular endothelium
16. A novel catheterization technique for the in vivo measurement of pulmonary vascular responses in the rat
17. Adrenomedullin stimulates cyclic Amp formation in rat vascular smooth muscle cells
18. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
19. Amylin and CGRP induce insulin resistance via a receptor distinct from cAMP-coupled CGRP receptor
20. Renal responses to intra-arterial administration of adrenomedullin in dogs
21. Mechanism of vascular relaxation by the calcitonin gene-related peptide
22. Pulmonary vasodilator responses to adrenomedullin are reduced by NOS inhibitors in rats but not in cats
23. An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat
24. Molecular physiology of amylin
25. Molecular pharmacology of receptors for calcitonin gene-related peptide, amylin, and adrenomedullin
26. + currents in rabbit arterial smooth muscle via protein kinase
27. Comparison of responses to adrenomedullin and adrenomedullin analogs in the mesenteric vascular bed of the cat
28. Synthetic human adrenomedullin and adrenomedullin-(15-52) have potent short-lived vasodilator activity in the hindlimb vascular bed of the cat
29. Amylin-induced relaxation of the perfused mesenteric arterial bed: Mediation by CGRP receptors
30. The molecular pharmacology of CGRP and related peptide receptor subtypes