Non-peptidic chymase inhibitors

Expert Opinion on Therapeutic Patents

Volumn 11, Issue 9, 2001, Pages 1423-1428

  Aoyama, Y ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Cardiovascular disease; Chymase; Enzyme inhibitor; Fibrosis; Inflammatory disease; Serine protease

Indexed keywords

1 OXACEPHEM DERIVATIVE; ANGIOTENSIN; ANGIOTENSIN I; BENZENE DERIVATIVE; BENZOXAZOLE DERIVATIVE; BETA LACTAM DERIVATIVE; CATHEPSIN G; CEPHALOSPORIN DERIVATIVE; CHYMASE; CHYMOTRYPSIN A; CHYMOTRYPSIN INHIBITOR; COLLAGEN TYPE 1; DIPEPTIDYL CARBOXYPEPTIDASE; ELASTASE; ENDOTHELIN; ENZYME INHIBITOR; GELATINASE B; HISTAMINE; INTERLEUKIN 1BETA; MATRIX PROTEIN; PEPTIDE DERIVATIVE; PLASMIN; PYRIMIDINONE DERIVATIVE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; STEM CELL FACTOR; SULFONE DERIVATIVE; THROMBIN; TRYPSIN; UNINDEXED DRUG;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ASTHMA; CARDIOVASCULAR DISEASE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DERMATITIS; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; HAMSTER; HEART FAILURE; HUMAN; HYPERTENSION; INFLAMMATORY DISEASE; MALE; NONHUMAN; PATENT; PATHOPHYSIOLOGY; PUBLICATION; RAT; REVIEW; RHEUMATOID ARTHRITIS; STRUCTURE ANALYSIS;

EID: 0034878252     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.11.9.1423     Document Type: Review

References (26)

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3. Increased chymase-dependent angiotensin II formation in human atherosclerotic aorta
4. Chymase processes big-endothelin-2 to endothelin-2-(1-31) that induces contractile responses in the isolated monkey trachea
5. Chymase is activated in the hamster heart following ventricular fibrosis during the chronic stage of hypertension
6. Inhibition of chymase as mast cell-stabilizing agents: Contribution of chymase in the activation of human mast cells
7. Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase
8. Chymase cleavage of stem cell factor yields a bioactive, soluble product
9. Association between genetic variants of mast-cell chymase and eczema
10. Association between mast cell chymase genotype and atopic eczema: Comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease
11. Cleavage of Type I procollagen by human mast cell chymase initiates collagen fibril formation and generates a unique carboxyl-terminal propeptide
12. Dog mast cell alpha-chymase activates progelatinase B by cleaving the Phe88-Gln89 and Phe91-Glu92 bonds of the catalytic domain
13. Activation of angiotensin II-forming chymase in the cardiomyopatic hamster heart
14. Increased expression of mast cell chymase in the lungs of patients with congenital heart disease associated with early pulmonary vascular disease
15. Inhibition of chymase reduces vascular proliferation in dog-grafted veins
16. Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors
17. 1-Oxacephen-based human chymase inhibitors: Discovery of stable inhibitors in human plasma
18. Effect of a chymase inhibitor in a hamster sponge implant model
19. Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors
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21. Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase
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