PNA synthesis using a novel Boc/acyl protecting group strategy

Journal of Peptide Science

Volumn 7, Issue 8, 2001, Pages 402-412

  Kofoed, Thomas ^a,b   Hansen, Henrik F ^a   ørum, Henrik ^a   Koch, Troels ^a  

^a PNA Diagnostics A/S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Nucleic acid analogues; Peptide nucleic acid monomers; PNA synthesis; Protecting groups; Solid phase synthesis

Indexed keywords

ADENINE DERIVATIVE; CARBONYL DERIVATIVE; CYTOSINE DERIVATIVE; DNA; GLASS; GUANINE DERIVATIVE; HETEROCYCLIC AMINE; MONOMER; PEPTIDE NUCLEIC ACID; POLYSTYRENE; REAGENT;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIMERA; CONTROLLED STUDY; NUCLEIC ACID ANALYSIS; NUCLEIC ACID SYNTHESIS; OLIGOMERIZATION; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; POROSITY; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

BIOCHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; MODELS, CHEMICAL; NUCLEIC ACID CONFORMATION; PEPTIDE NUCLEIC ACIDS;

EID: 0034877076     PISSN: 10752617     EISSN: None     Source Type: Journal    
DOI: 10.1002/psc.333     Document Type: Article

References (16)

1. Sequence selective recognition of DNA by strand displacement with a thymine-substituted polyamide
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5. Synthesis of polyamide nucleic acids (PNAs) using a novel Fmoc/Mmt protecting-group combination
6. Solid phase synthesis of directly linked PNA-DNA hybrids
7. Solid-phase synthesis of peptide nucleic acids
8. Improvements in automated PNA synthesis using Boc/Z monomers
9. Impact of biophysical parameters on the biological assessment of peptide nucleic acids, antisense inhibitors of gene expression
10. PNA solubility enhancers
11. PNA: Synthetic polyamide nucleic acids with unusual binding properties
12. Mono-protected diamines
13. Synthesis of peptide nucleic acid monomers containing the four natural nucleobases: Thymine, cytosine, adenine, and guanine and their oligomerisation
14. 4-benzoylated cytosine
15. Improved synthesis of 4-(boc-aminoacyloxymethyl)-phenylacetic acid for use in solid phase peptide synthesis
16. In situ neutralization in Boc-chemistry solid phase peptide synthesis