Do fits really beget fits? The effect of previous epileptic activity on the subsequent induction of the tetanus toxin model of limbic epilepsy in the rat

Neurobiology of Disease

Volumn 8, Issue 4, 2001, Pages 679-691

  Mellanby, J ^a   Milward, A J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Epilepsy; Kainic acid; Phenobarbital; Tetanus toxin

Indexed keywords

KAINIC ACID; PHENOBARBITAL; TETANUS TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; EPILEPSY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; LIMBIC CORTEX; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0034877004     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2001.0417     Document Type: Article

References (53)

1. Alterations in GABAA receptor alpha1 and alpha4 subunit mRNA levels in thalamic relay nuclei following absence-like seizures in rats
2. Use dependent regulation of GABAa receptors
3. Simultaneous expression of long-term depression of NMDA and long-term potentiation of AMPA receptor-mediated synaptic responses in the CA1 area of the kainic acid-lesioned hippocampus
4. Long-term changes in hippocampal physiology and learning ability of rats after intrahippocampal tetanus toxin
5. Effects of kindling or brain stimulation on pentylenetetrazol-induced convulsion susceptibility
6. Transfer of pentylenetetrazol sensitization to amygdaloid kindling
7. Bidirectional transfer of intracerebrally administered pentylenetetrazol and electrical kindling
8. Bidirectional transfer of electrical and carbachol kindling
9. Kindling by repeated intraperitoneal or intracerebral injection of picrotoxin transfers to electrical kindling
10. Chronic/semichronic limbic epilepsy produced by microinjection of tetanus toxin in cat hippocampus
11. Synaptic inhibition in primary and secondary chronic epileptic foci induced by intrahippocampal tetanus toxin in the rat
12. Increased susceptibility to hippocampal and amygdala kindling following intrahippocampal kainic acid
13. Do kainate-lesioned hippocampi become epileptogenic?
14. Inhibition in kainate-lesioned hyperexcitable hippocampi: Physiologic, autoradiographic and immunocytochemical observations
15. Development of epileptic seizures through brain stimulation at low intensity
16. Kainic acid-induced seizures enhance dentate gyrus inhibition by down-regulation of GABAb receptors
17. Limbic epilepsy induced by tetanus toxin: A longitudinal electroencephalographic study
18. Recurrent spontaneous motor seizures after repeated low dose systemic treatment with kainate: Assessment of a rat model of temporal lobe epilepsy
19. Chronic epileptic foci in vitro in hippocampal slices from rats with the tetanus toxin epileptic syndrome
20. 'Dormant' inhibitory neurons: Do they exist and what is their functional impact?
21. Physiological and behavioural consequences of seizures induced in the rat by intrahippocampal tetanus toxin
22. Loss of inhibition precedes delayed spontaneous seizures in the hippocampus after tetanic electrical stimulation
23. Abnormal neuronal excitability in hippocampal slices from kindled rats
24. Kindling increases N-methyl-D-aspartate potency at single N-methyl-D-aspartate channels in dentate gyrus granule cells
25. Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats
26. Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat
27. Anticonvulsant drugs: Mechanisms of action
28. Epileptic brain damage: A consequence and a cause of seizures
29. Tetanus toxin as a tool for investigating the consequences of excessive neuronal excitation
30. Long-term reduction in inhibition in rat dentate gyrus after intrahippocampal tetanus toxin
31. Kindling, behaviour and memory
32. Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus
33. Behavioural correlates of an experimental hippocampal epileptiform syndrome in rats
34. Ganglioside as a prophylactic agent in experimental tetanus in mice
35. Development of spontaneous seizures over extended electrical kindling. II. Persistence of dentate inhibitory suppression
36. Changes in inhibitory processes in the hippocampus following recurrent seizures induced by systemic administration of kainic acid
37. Forebrain ischaemia with CA1 cell loss impairs epileptogenesis in the tetanus toxin limbic seizure model
38. Kindling-related changes in after discharge 'thresholds'
39. Phenobarbital in the genetically obese Zucker rat. I. Pharmacokinetics after acute and chronic administration
40. The contribution of non-NMDA and NMDA receptors to graded bursting activity in the CA1 region of the hippocampus in a chronic model of epilepsy
41. Permanently altered hippocampal structure, excitability and inhibition after experimental status epilepticus in the rat: The 'dormant basket cell' hypothesis and its relevance to temporal lobe epilepsy
42. Bilateral reorganisation of mossy fibres in the rat hippocampus after a unilateral intracerebroventricular kainic acid injection
43. Alteration of long-lasting structural and functional effects of kainic acid in the hippocampus by brief treatment with phenobarbital
44. Chronic administration of antipanic drugs alters brainstem GABAA receptor subunit mRNA levels
45. The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rats. I. Paired-pulse depression
46. The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. II. Receptor binding
47. Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons
48. Review of the role of inhibitory neurons in chronic epileptic foci induced by intracerebral tetanus toxin
49. Effects of hippocampal kindling on paired-pulse response in CA1 in vitro
50. Hippocampal kindling induced paired-pulse depression in the dentate gyrus and paired-pulse facilitation in CA3