Reduced p21WAF1/CIP1 Expression is an early event in gallbladder carcinogenesis and is of prognostic significance for patients with carcinomas of the gallbladder

Human Pathology

Volumn 32, Issue 8, 2001, Pages 771-777

  Li, Xin ^a   Hui, Ai Min ^a   Shi, Ya Zhou ^a   Takayama, Tadatoshi ^a   Makuuchi, Masatoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Gallbladder carcinoma; P21WAF1 CIP1; P53; Precancerous lesion; Prognosis

Indexed keywords

PROTEIN P21; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER STAGING; CARCINOGENESIS; CLINICAL ARTICLE; DIAGNOSTIC VALUE; DISEASE COURSE; GALLBLADDER CARCINOMA; HUMAN; HUMAN TISSUE; PROGNOSIS; PROTEIN EXPRESSION;

EID: 0034875360     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2001.26474     Document Type: Article

References (35)

1. The histogenesis of adenocarcinoma of the gallbladder
2. Relation of adenoma to carcinoma in the gallbladder
3. The WHO histological classification of tumors of the gallbladder and extrahepatic bile ducts. A commentary on the second edition
4. Non-neoplastic polypoid lesions and adenomas of the gallbladder
5. Association of Bcl-2 protein expression with gallbladder carcinoma differentiation and progression and its relation to apoptosis
6. A genetic model for colorectal tumorigenesis
7. p53 mutations in human cancers
8. WAF1, a potential mediator of p53 tumor suppression
9. p21 is a universal inhibitor of cyclin kinases
10. WAF1
11. Absence of WAF1 mutations in a variety of human malignancies
12. Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia
13. WAF1/CIP1 in normal, hyperplastic, and neoplastic uterine tissues
14. p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis
15. Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma
16. WAF1/CIP1 in malignant melanoma
17. Primary gallbladder carcinoma: Significance of subserosal lesions and results of aggressive surgical treatment and adjuvant chemotherapy
18. Prognostic factors in the surgical treatment of gallbladder carcinoma
19. Carcinoma of the gallbladder: A clinicopathology of 103 patients and a newly proposed staging
20. Long-term results after curative resection for carcinoma of the gallbladder
21. Retrospective analysis of 70 operations for gallbladder carcinoma
22. Outcome of radical surgery for carcinoma of the gallbladder according to the TNM stage
23. TNM Classification of Malignant Tumors (ed 5)
24. Histological Typing of Tumours of the Gallbladder and Extrahepatic Bile Ducts. World Health Organization International Histological Classification of Tumours (ed 2)
25. Over-expression and lack of retinoblastoma protein are associated with tumor progression and metastasis in hepatocellular carcinomas
26. Immunohistochemical studies on Waf1 p21, p16, pRb and p53 in human esophageal carcinomas and neighboring epithelia from a high-risk area in Northern China
27. Prognostic significance of Ki-67 and p53 antigen expression in carcinomas of bile duct and gallbladder
28. Loss of function and p 53 protein stabilization
29. Mutations of p53 in gallbladder carcinomas in high-incidence areas of Japan and Chile
30. p53 protein expression and prognosis in gallbladder carcinoma and premalignant lesions
31. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
32. Transforming growth factor induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
33. WAF1/CIP1 expression and p53 mutation in hepatocellular carcinomas
34. WAF1/CIP1 protein expression is predominantly related to altered p53 in hepatocellular carcinomas