Compression shear strength and tableting behavior of microcrystalline cellulose agglomerates modulated by a solution binder (polyethylene glycol)

Pharmaceutical Research

Volumn 18, Issue 6, 2001, Pages 873-877

  Nicklasson, F ^a   Alderborn, G ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Agglomerate deformation; Agglomerate porosity; Compression shear strength; Solution binder; Tablet pore structure; Tablet tensile strength

Indexed keywords

DRUG; MACROGOL;

ARTICLE; DRUG MIXTURE; POROSITY; PRIORITY JOURNAL; SHEAR STRESS; TABLET COMPRESSION; TABLET FORMULATION; TABLET PROPERTY; TENSILE STRENGTH;

CELLULOSE; COMPRESSIVE STRENGTH; EXCIPIENTS; POLYETHYLENE GLYCOLS; POROSITY; SOLVENTS; TABLETS; TENSILE STRENGTH;

EID: 0034872092     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011057000748     Document Type: Article

References (21)

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11. Die pulverkompression
12. Agglomerate strength measurement using a uniaxial confined compression test
13. Compression behaviour and compactability of microcrystalline cellulose pellets in relationship to their pore structure and mechanical properties
14. Modulation of the tabletting behaviour of microcrystalline cellulose pellets by the incorporation of polyethylene glycol
15. The effect of water content on the porosity and liquid saturation of extruded cylinders
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18. Studies on direct compression of tablets. XI. Characterization of particle fragmentation during compaction by permeametry measurements of tablets
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20. Degree of pellet deformation during compaction and its relationship to the tensile strength of tablets formed of microcrystalline cellulose pellets
21. Tabletting behaviour of pellets of a series of porosities - A comparison between pellets of two different compositions