p-aminobenzoic acid and chloramphenicol biosynthesis in Streptomyces venezuelae: Gene sets for a key enzyme, 4-amino-4-deoxychorismate synthase

Microbiology

Volumn 147, Issue 8, 2001, Pages 2113-2126

  Chang, Z ^a   Sun, Y ^a   He, J ^a   Vining, L C ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

p aminobenzoate synthase genes; Primary and secondary metabolism

Indexed keywords

4 AMINO 4 DEOXYCHORISMATE SYNTHASE; 4 AMINOBENZOIC ACID; CHLORAMPHENICOL; PRIMER DNA; SULFADIMIDINE; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIUM ISOLATION; BIOSYNTHESIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DATA BASE; ESCHERICHIA COLI; GENE AMPLIFICATION; GENE DISRUPTION; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; HOST; HYBRIDIZATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROKARYOTE; PROTEIN DOMAIN; SEQUENCE ANALYSIS; STREPTOMYCES LIVIDANS; STREPTOMYCES VENEZUELAE; TRANSCRIPTION REGULATION;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PROKARYOTA; STREPTOMYCES LIVIDANS; STREPTOMYCES VENEZUELAE; UNCULTURED ACTINOMYCETE;

EID: 0034871643     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-147-8-2113     Document Type: Article

References (42)

1. Approaches to the cloning of genes for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230
2. Plasmid transformation of Streptomyces venezuelae: Modified procedures used to introduce the genes for p-aminobenzoate synthetase
3. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
4. A role for pabAB, a p-aminobenzoate synthase gene of Streptomyces venezuelae ISP5230, in chloramphenicol biosynthesis
5. Genes for cysteine biosynthesis and metabolism in Streptomyces venezuelae ISP5230: Cloning, sequencing, functional analysis and relevance to chloramphenicol biosynthesis
6. Physical identification of a chromosomal locus encoding biosynthetic synthetic genes for the lipopeptide calcium-dependent antibiotic (CDA) of Streptomyces coelicolor A3(2)
7. A comprehensive set of sequence analysis programs for the VAX
8. Conjugational fertility and location of chloramphenicol biosynthesis genes on the chromosomal linkage map of Streptomyces venezuelae
9. Para-aminobenzoate synthase gene of Saccharomyces cerevisiae encodes a bifunctional enzyme
10. High-efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes
11. Cloning and expression of a p-aminobenzoic acid synthase gene of the candicidin-producing Streptomyces griseus
12. Nucleotide sequence of Escherichia coli pabB indicates a common evolutionary origin of p-aminobenzoate synthetase and anthranilate synthetase
13. Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme
14. Role of p-aminophenylalanine in the biosynthesis of chloramphenicol
15. Unidirectional deletion with exonuclease III creates targeted breakpoints for DNA sequencing
16. Using CLUSTAL for multiple sequence alignments
17. Genetic analysis and genome structure in Streptomyces coelicolor
18. Biosynthesis of chloramphenicol in Streptomyces sp. 3022a. Identification of p-amino-L-phenylalanine as a product from the action of arylamine synthetase on chorismic acid
19. The minimal replicon of a streptomycete plasmid produces an ultrahigh level of plasmid DNA
20. Regulation of an anthranilate synthase gene in Streptomyces venezuelae by a trp attenuator
21. Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector
22. Metabolism of chloramphenicol by the producing organism
23. Intergeneric conjugation between Escherichia coli and Streptomyces species
24. A cmr study of the biosynthesis of chloramphenicol
25. Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus
26. A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome
27. DNA sequencing with chain-terminating inhibitors
28. A rapid screening procedure for identification of recombinant bacterial clones
29. Biosynthesis of chloramphenicol II. p-Amino-phenylalanine as a precursor of the p-nitrophenylserinol moiety
30. An apparent Bacillus subtilis folic acid biosynthetic operon containing pab, an amphibolic trpG gene, a third gene required for synthesis of para-aminobenzoic acid, and the dihydropteroate synthase gene
31. Detection of specific sequences among DNA fragments separated by gel electrophoresis
32. Temperate phages of Streptomyces venezuelae: Lysogeny and host specificity shown by SV1 and SV2
33. Characterization of different plasmid-borne dihydropteroate synthases mediating bacterial resistance to sulfonamides
34. Total biosynthesis of 4-amino-4-deoxychorismic acid: A key intermediate in the biosynthesis of p-aminobenzoic acid and L-p-aminophenylalanine
35. Biochemical characterization of resistance determinants cloned from antibiotic-producing streptomycetes
36. Transductional analysis of chloramphenicol biosynthesis genes in Streptomyces venezuelae
37. Chloramphenicol
38. Codon usage in the G + C-rich Streptomyces genome