The role of Bapx1 (Nkx3.2) in the development and evolution of the axial skeleton

Journal of Anatomy

Volumn 199, Issue 1-2, 2001, Pages 181-187

  Lettice, Laura ^a   Hecksher SØrensen, Jacob ^a   Hill, Robert ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Axial skeleton; Bapx1; Development; Evolution; Nkx3.1

Indexed keywords

HOMEODOMAIN PROTEIN;

AMPHIBIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRD; BONE DEVELOPMENT; CONTROLLED STUDY; DROSOPHILA; DUODENUM; EMBRYO; EMBRYO DEVELOPMENT; EVOLUTION; FETUS; FISH; GENE MUTATION; GENETIC ANALYSIS; HOMEOBOX; INTERVERTEBRAL DISK; INTESTINE MUSCLE; MAMMAL; MESENCHYME; MESODERM; MOUSE; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; SKELETON; SPLEEN; STOMACH; VERTEBRATE;

ANIMALS; BASE SEQUENCE; BONE AND BONES; EVOLUTION; GENE EXPRESSION; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; MAMMALS; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; MUTATION; SEQUENCE HOMOLOGY, AMINO ACID; SKELETON; TRANSCRIPTION FACTORS;

AMPHIBIA; ANIMALIA; AVES; MAMMALIA; VERTEBRATA;

EID: 0034871175     PISSN: 00218782     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0021878201008287     Document Type: Article

References (30)

1. Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation
2. Tinman and bagpipe: Two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila
3. Roles for Nkx3.1 in prostate development and cancer
4. Evolution and development of distinct cell lineages derived from somites
5. Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
6. NK-2 homeobox genes and heart development
7. Gene duplications and the origins of vertebrate development
8. A cluster of Drosophila homeobox genes involved in mesoderm differentiation programs
9. Drosophila NK-homeobox genes
10. The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column
11. The mouse bagpipe gene controls development of axial skeleton, skull, and spleen
12. Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9
13. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
14. Xbap, a vertebrate gene related to bagpipe, is expressed in developing craniofacial structures and in anterior gut muscle
15. The Xenopus bagpipe-related homeobox gene zampogna is expressed in the pharyngeal endoderm and the visceral musculature of the midgut
16. Two Nkx-3-related genes are expressed in the adult and regenerating central nervous system of the urodele Pleurodeles waltl
17. Zebrafish Pax9 encodes two proteins with distinct C-terminal transactivating domains of different potency negatively regulated by adjacent N-terminal sequences
18. Pax1/Pax9-related genes in an agnathan vertebrate, Lampetra japonica: Expression pattern of LjPax9 implies sequential evolutionary events toward the gnathostome plan
19. Pax1 and Pax9 synergistically regulate vertebral column development
20. Evidence for 14 homeobox gene clusters in human genome ancestry
21. The homeobox gene NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos
22. Targeted disruption of the nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: Parallels to glandular duct morphogenesis in prostate
23. Nkx3.1, a murine homolog of Drosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands
24. Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe
25. The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen
26. Bapx1: An evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton
27. The role of Pax-1 in axial skeleton development
28. Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency
29. The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo