Signal transduction in smooth muscle selected contribution: HSP20 phosphorylation in nitroglycerin- and forskolin-induced sustained reductions in swine carotid media tone

Journal of Applied Physiology

Volumn 91, Issue 3, 2001, Pages 1460-1466

  Rembold, Christopher M ^a,b   O'Connor, Matthew ^a   Clarkson, Michael ^a   Wardle, Robert L ^b   Murphy, Richard A ^b  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Adenosine 3 ,5 cyclic monophosphate; Calcium ion concentration; Guanosine 3 ,5 cyclic monophosphate; Heat shock proteins; Nitric oxide; Vascular smooth muscle

Indexed keywords

CALCIUM ION; CYCLIC AMP; CYCLIC GMP; FORSKOLIN; GLYCERYL TRINITRATE; HEAT SHOCK PROTEIN; HISTAMINE; MYOSIN LIGHT CHAIN; NITRIC OXIDE; SERINE; CALCIUM; HEAT SHOCK PROTEIN 20; PHOSPHOPROTEIN; VASODILATOR AGENT;

ANIMAL TISSUE; ARTERY MEDIA; ARTICLE; CALCIUM CELL LEVEL; CAROTID ARTERY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION FUNCTION; MUSCLE FORCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REDUCTION; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; SWINE; VASCULAR SMOOTH MUSCLE; ANIMAL; COMMON CAROTID ARTERY; DRUG EFFECT; IN VITRO STUDY; METABOLISM; MUSCLE RELAXATION; MUSCLE TONE; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CAROTID ARTERY, COMMON; CYCLIC AMP; CYCLIC GMP; FORSKOLIN; HEAT-SHOCK PROTEINS; HSP20 HEAT-SHOCK PROTEINS; MUSCLE RELAXATION; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITROGLYCERIN; PHOSPHOPROTEINS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SWINE; VASODILATOR AGENTS;

EID: 0034871125     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2001.91.3.1460     Document Type: Article

References (29)

1. Protein phosphorylation during contraction and relaxation
2. Dissociation of relaxation and myosin light chain dephosphorylation in porcine uterine muscle
3. The small heat shock-related protein, HSP20, is phosphorylated on serine 16 during cyclic nucleotide-dependent relaxation
4. Cyclic nucleotide-dependent vasorelaxation is associated with the phosphorylation of a small heat shock-related protein
5. The small heat shock-related protein-20 is an actin-associated protein
6. cGMP mediates corpus cavernosum smooth muscle relaxation with altered cross-bridge function
7. 2+]
8. Dissociation of myosin phosphorylation and active tension during muscarinic stimulation of tracheal smooth muscle
9. 2+, myosin phosphorylation, and relaxation of arterial smooth muscle
10. 2+, crossbridge phosphorylation, and contraction
11. Myosin phosphatase: Subunits and interactions
12. Mechanisms of smooth muscle contraction
13. Endothelial-dependent vasodilation is associated with increases in the phosphorylation of a small heat shock protein (HSP20)
14. 2+ antagonists on myosin light chain phosphorylation in relaxation of endothelin-1-contracted tracheal smooth muscle
15. Phosphorylation-dephosphorylation of enzymes
16. The nitric oxide-cyclic GMP signaling system
17. 2+ by cAMP in vascular smooth muscle cells
18. i sensitivity, and uncoupling stress from myosin phosphorylation
19. Cyclic nucleotide dependent relaxation in vascular smooth muscle
20. 2+]
21. Effect of phosphorylation on the actin-activated ATPase activity of myosin
22. i, and the latch-bridge hypothesis in swine arterial smooth muscle
23. Electromechanical and pharmacomechanical coupling
24. cGMP mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation
25. 2+] determines myosin phosphorylation in agonist-stimulated swine arterial smooth muscle
26. Caldesmon and heat shock protein 20 in nitroglycerin- and magnesium induced relaxation of swine carotid artery
27. Okadaic acid uncouples myosin light chain phosphorylation and tension in smooth muscle
28. Nitroglycerin-induced relaxation of histamine-contracted swine carotid artery smooth muscle: A cGMP-dependent, myosin phosphorylation-independent mechanism
29. 2+-dependent contraction in swine carotid artery by myosin kinase inhibitors