Accumulation of molecules involved in α1-adrenergic signal within caveolae: Caveolin expression and the development of cardiac hypertrophy

Cardiovascular Research

Volumn 51, Issue 4, 2001, Pages 709-716

  Fujita, Takayuki ^a   Toya, Yoshiyuki ^a   Iwatsubo, Kousaku ^a   Onda, Takeshi ^a   Kimura, Kazuo ^a   Umemura, Satoshi ^a   Ishikawa, Yoshihiro ^a,b  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Diabetes; Hypertrophy; Receptors; Signal transduction; Smooth muscle

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CAVEOLIN; CAVEOLIN 1; CAVEOLIN 3; RADIOLIGAND; RECEPTOR SUBTYPE;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; HEART VENTRICLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; RAT; RECEPTOR BINDING; SMOOTH MUSCLE FIBER; SPECIES DIFFERENCE; TISSUE DISTRIBUTION; VASCULAR SMOOTH MUSCLE;

ANALYSIS OF VARIANCE; ANIMALS; CARDIOMEGALY; CAVEOLAE; CAVEOLIN 1; CAVEOLIN 3; CAVEOLINS; CELL FRACTIONATION; CELL LINE; CELLS, CULTURED; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HETEROTRIMERIC GTP-BINDING PROTEINS; IMMUNOBLOTTING; MALE; MUSCLE, SMOOTH, VASCULAR; PHOSPHOLIPASE C; PRECIPITIN TESTS; RADIOLIGAND ASSAY; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; SIGNAL TRANSDUCTION;

EID: 0034869686     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00348-0     Document Type: Article

References (29)

1. Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells
2. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
3. Caveolin is an inhibitor of platelet-derived growth factor receptor signaling
4. Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1
5. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade
6. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells
7. The adenylyl cyclases as integrators of transmembrane signal transduction
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10. Inhibition of adenylyl cyclase by caveolin peptides
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12. The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy
13. Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation
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28. Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase
29. Plasma and lipoprotein lipid composition and hepatic antioxidant status in spontaneously hypertensive (SHR) and normotensive (WKY) rats