Accumulation of molecules involved in α1-adrenergic signal within caveolae: Caveolin expression and the development of cardiac hypertrophy

Cardiovascular Research

Volumn 51, Issue 4, 2001, Pages 709-716

  Fujita, Takayuki ^a   Toya, Yoshiyuki ^a   Iwatsubo, Kousaku ^a   Onda, Takeshi ^a   Kimura, Kazuo ^a   Umemura, Satoshi ^a   Ishikawa, Yoshihiro ^a,b  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Diabetes; Hypertrophy; Receptors; Signal transduction; Smooth muscle

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CAVEOLIN; CAVEOLIN 1; CAVEOLIN 3; RADIOLIGAND; RECEPTOR SUBTYPE;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; HEART VENTRICLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; RAT; RECEPTOR BINDING; SMOOTH MUSCLE FIBER; SPECIES DIFFERENCE; TISSUE DISTRIBUTION; VASCULAR SMOOTH MUSCLE;

ANALYSIS OF VARIANCE; ANIMALS; CARDIOMEGALY; CAVEOLAE; CAVEOLIN 1; CAVEOLIN 3; CAVEOLINS; CELL FRACTIONATION; CELL LINE; CELLS, CULTURED; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HETEROTRIMERIC GTP-BINDING PROTEINS; IMMUNOBLOTTING; MALE; MUSCLE, SMOOTH, VASCULAR; PHOSPHOLIPASE C; PRECIPITIN TESTS; RADIOLIGAND ASSAY; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; SIGNAL TRANSDUCTION;

EID: 0034869686     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00348-0     Document Type: Article

References (29)

1. Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells
2. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
3. Caveolin is an inhibitor of platelet-derived growth factor receptor signaling
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