Optimal adaptive designs for binary response trials

Biometrics

Volumn 57, Issue 3, 2001, Pages 909-913

  Rosenberger, William F ^a,b   Stallard, Nigel ^c   Ivanova, Anastasia ^d   Harper, Cherice N ^a   Ricks, Michelle L ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF READING   (United Kingdom)

^d IL   (United States)

Author keywords

Clinical trials; Ethics; Expected treatment failures; Neyman allocation; Power; Randomized play the winner rule; Sequential design

Indexed keywords

STATISTICAL TESTS;

ADAPTIVE DESIGNS; CLINICAL TRIAL; EXPECTED TREATMENT FAILURE; NEYMAN ALLOCATION; OPTIMAL ALLOCATION; PLAY-THE-WINNER RULE; POWER; RANDOMIZED PLAY-THE-WINNER RULE; SEQUENTIAL DESIGN; TREATMENT FAILURE;

MEDICAL APPLICATIONS;

BIOMETRY;

ADAPTATION; ARTICLE; ETHICS; MATHEMATICAL ANALYSIS; PROBABILITY; RESEARCH; SIMULATION; STATISTICS; TREATMENT FAILURE;

EID: 0034862727     PISSN: 0006341X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0006-341X.2001.00909.x     Document Type: Article

References (11)

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5. Asymptotic normality of maximum likehood estimators from multiparameter response-driven designs
6. A reeveluation of the role of crystalloid preload in the prevention of hypotension associated with spinal anesthesia for elective cesarean section
7. The randomized play-the-winner rule in medical trials