Retinoic acid down-regulates VPAC1 receptors and TGF-β3 but up-regulates TGF-β2 in lung cancer cells

Peptides

Volumn 21, Issue 12, 2000, Pages 1831-1837

  Jakowlew, Sonia B ^a   Zakowicz, Halina ^a   Moody, Terry W ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

cAMP; Lung cancer; Retinoic acid; Transforming growth factor ; VIP receptors

Indexed keywords

CYCLIC AMP; IODINE 125; MESSENGER RNA; RECEPTOR; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR; VPAC 1 RECEPTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27; INSULIN; ISOTRETINOIN; TRANSFERRIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SCATCHARD PLOT; CANCER CELL; DOSE TIME EFFECT RELATION; INCUBATION TIME; LUNG CANCER; NORTHERN BLOTTING; RECEPTOR AFFINITY;

BINDING SITES; CELL DIVISION; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; KINETICS; LUNG NEOPLASMS; PROTEIN BINDING; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; RECEPTORS, VASOACTIVE INTESTINAL POLYPEPTIDE, TYPE I; RNA, MESSENGER; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TRETINOIN; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0034861164     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(00)00344-2     Document Type: Article

References (49)

1. Distinct regulation of vasoactive intestinal peptide (VIP) expression at mRNA and peptide levels in human neuroblastoma cells
2. Pituitary adenylate cyclase activating polypeptide (PACAP): Discovery and current status of research
3. Differential regulation of the expression of transforming growth factor-βs 1 and 2 by retinoic acid, epidermal growth factor and dexamethasone in NRK-49F and A549 cells
4. Cloning of a TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor
5. Retinoic acid induces transforming growth factor-β2 in cultured keratinocytes and mouse epidermis
6. The VIP gene is expressed in non-small cell lung cancer cell lines
7. An antagonist to vasoactive intestinal peptide affects cellular function in the central nervous system
8. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide
9. Expression of transforming growth factor-β2 and 3 mRNAs and proteins in the developing chicken embryo
10. Differential regulation of the expression of transforming growth factor-β mRNAs by growth factors and retinoic acid in chicken embryo chondrocytes, myocytes and fibroblasts
11. Complementary deoxyribonucleic acid cloning of an mRNA encoding transforming growth factor-β-4 from chicken embryo chondrocytes
12. Identification and characterization of the chicken transforming growth factor-β3 promoter
13. Role of nuclear retinoic acid receptors in the regulation of gene expression
14. Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene
15. The retinoid X receptors: Modulators of multiple hormonal signaling pathways
16. Expression of nerve growth factor receptor mRNAs and clinical response to retinoic acid in neuroblastoma
17. Secretin/VIP stimulated secretion of bombesin-like peptides from human small cell lung cancer
18. Vasoactive intestinal polypeptide binds with high affinity to non-small cell lung cancer cells and elevates cAMP levels
19. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
20. Cancer chemoprevention
21. Retinoic acid down-regulates the expression of the vasoactive intestinal polypeptide receptor type-1 in human breast carcinoma cell lines
22. The transforming growth factor-β family
23. Human small cell lung carcinoma inhibition by vasoactive intestinal peptide (VIP) and helodermin (Hd)
24. VIP analogues inhibit small cell lung cancer growth
25. A VIP antagonist inhibits the growth of non-small cell lung cancer
26. 17)VIPhybrid is a potent non-small cell lung cancer VIP receptor antagonist
27. Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site
28. Vasoactive intestinal peptide: Autocrine growth factor in neuroblastoma
29. In vitro differentiation of human neuroblastoma cells caused by vasoactive intestinal peptide
30. VIP regulates mitosis, differentiation and survival of cultured sympathetic neuroblasts
31. Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type I receptor
32. In vitro identification of vasoactive intestinal peptide receptors in human tumors: Implications for tumor imaging
33. Multiple forms of TGF-β: Distinct promoters and differential expression
34. Polypeptide with broad biological activity: Isolation from the small intestine
35. Inhibition of rabbit collagenase (Matrix metalloproteinase-1) transcription by retinoic receptor: Evidence for binding of RATs/RXTs to the -77 AP-1 site through interactions with c-Jun
36. High affinity binding of VIP to human lung cancer cell lines
37. Molecular cloning of sequences regulated during squamous differentiation of tracheal epithelial cells and controlled by retinoic acid
38. Differential signal transduction by five splice variants of the PACAP receptor
39. Autocrine growth factors and cancer
40. The expression of multiple proto-oncogenes is differentially regulated during retinoic acid induced maturation of human neuroblastoma cell lines
41. Vasoactive intestinal peptide receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors
42. Molecular cloning of gene sequences transcriptionally regulated by retinoic acid and dibutyryl cyclic AMP in cultured mouse teratocarcinoma cells
43. Lineage specific regulation of the vasoactive intestinal peptide gene in neuroblastoma cells is conferred by 5.2 kilobases of 5′ flanking sequence
44. Retinoic acid enhances VIP receptor expression and responsiveness in human neuroblastoma cell SH-SY5Y
45. Differential expression of VIP/PACAP receptor genes in breast, intestinal and pancreatic lines
46. Retinoic acid regulation of the VIP and PACAP autocrine ligand and receptor system in human neuroblastoma cell lines
47. Breast cancer growth is inhibited by vasoactive intestinal peptide hybrid, a synthetic VIP receptor antagonist