Blockade of NMDA receptors by MK-801 reverses the changes in striatal glutamate immunolabeling in 6-OHDA-lesioned rats

Synapse

Volumn 42, Issue 1, 2001, Pages 54-61

  Robinson, Siobhan ^a   Krentz, Lisa ^b   Moore, Cynthia ^c   Meshul, Charles K ^a,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Electron microscopy; Glutamate receptor antagonist; Glutamate synapses; Immunocytochemistry; Parkinson's disease

Indexed keywords

APOMORPHINE; DIZOCILPINE; GLUTAMIC ACID; HALOPERIDOL; N METHYL DEXTRO ASPARTIC ACID; OXIDOPAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL GANGLION; CONTROLLED STUDY; CORPUS STRIATUM; ELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; MALE; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; SYNAPSE;

ADRENERGIC AGENTS; ANIMALS; CORPUS STRIATUM; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; IMMUNOCHEMISTRY; MALE; OXIDOPAMINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SUBSTANTIA NIGRA; SYNAPSES;

EID: 0034860916     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.1099     Document Type: Article

References (52)

1. MK-801 differentially affects dopamine D1 and D2 receptor agonist-induced behavioral tolerance and desensitization
2. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus
3. Subcellular and subsynaptic distribution of the NR1 subunit of the NMDA receptor in the neostriatum and globus pallidus of the rat: Co-localization at synapses with the GluR2/3 subunit of the AMPA receptor
4. Influence of previous exposure to levodopa on the interaction between dizocilpine and dopamine D1 and D2 agonists in rats with 6-hydroxydopamine lesions
5. Reduction of apomorphine-induced rotational behaviour by subthalamic lesion in 6-OHDA lesioned rats is associated with a normalization of firing rate and discharge pattern of pars reticulata neurons
6. Long-term potentiation in the striatum is unmasked by removing the voltage-dependent magnesium block of NMDA receptor channels
7. Electrophysiology of dopamine-denervated striatal neurons
8. Transection of corticostriatal afferents reduces amphetamine- and apomorphine-induced striatal Fos expression and turning behaviour in unilaterally 6-hydroxydopamine-lesioned rats
9. Lesion-induced axon sprouting in the deafferented striatum of adult rat
10. The neurological basis of motor asymmetry following unilateral 6-hydroxydopamine brains lesions in the rat: The effect of motor decortication
11. The development of behavioral sensitization to apomorphine is blocked by MK-801
12. Identification of synaptic terminals of thalamic or cortical origin in contact with distinct medium-size spiny neurons in the rat neostriatum
13. Excitatory amino acids receptor antagonists modify regional cerebral metabolic responses to levodopa in 6-hydroxydopamine-lesioned rats
14. Sensitization to apomorphine-induced rotational behavior in 6-OHDA-lesioned rats: Effects of NMDA antagonist on drug response
15. Glutamate-dopamine interactions in the basal ganglia: Relationship to Parkinson's disease
16. Chronic dizocilpine maleate (MK-801) treatment suppresses the effects of nigrostriatal dopamine deafferentation on enkephalin but not on substance P expression in the rat striatum
17. Nitric oxide as a retrograde messenger during long-term potentiation
18. Characterization of antisera to glutamate and aspartate
19. Circling behaviour in 6-hydroxydopamine-lesioned rats given pulsed levodopa is reduced more by lesions in the entopeduncular nucleus/substantia nigra pars reticulata than in the subthalamic nucleus
20. Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway
21. Bilateral regulation of glutamate tissue and extracellular levels in caudate-putamen by midbrain dopamine neurons
22. MK-801 prevents levodopa-induced motor response alterations in parkinsonian rats
23. The organization of the projection from the cerebral cortex to the striatum in the rat
24. Substantia nigra glutamate antagonists produce contralateral turning and basal ganglia Fos expression: Interactions with D1 and D2 dopamine receptor agonists
25. Haloperidol reverses the changes in striatal glutamatergic immunolabeling following a 6-OHDA lesion
26. Alterations in rat striatal glutamate synapses following a lesion of the cortico- and/or nigrostriatal pathway
27. Haloperidol-induced synaptic changes in striatum are associated with glutamate synapses
28. Activation of corticostriatal pathway leads to similar morphological changes observed following haloperidol treatment
29. Effects of subchronic clozapine and haloperidol on striatal glutamatergic synapses
30. Time-dependent changes in striatal glutamate synapses following a 6-hydroxydopamine lesion
31. Stereospecific blockade of N-methyl-D-aspartate transmission by MK 801 prevents priming of SKF 38393-induced turning
32. MK-801 potentiates dopaminergic D1 but reduces D2 responses in the 6-hydroxydopamine model of Parkinson's disease
33. Blockade of N-methyl-D-aspartate receptors potentiates dopaminergic responses in the 6-OHDA model of parkinson: Differential role of D-1 and D-2 receptors
34. 1-dependent contralateral turning and its relationship to c-fos expression in the rat caudate-putamen
35. Reevaluation of the striatal role in the expression of turning behavior in the rat model of Parkinson's disease
36. Plasticity of neostriatal dopamine receptors after nigrostriatal injury: Relationship to recovery of sensorimotor function and behavioral supersensitivity
37. Surgery for Parkinson's disease
38. Chronic L-dopa alters striatal NMDA receptors in rats with dopaminergic injury
39. Simultaneous microdialysis in striatum and substantia nigra suggests that the nigra is a major site of action of L-dihyroxyphenyalanine in the "Hemiparkinsonian" rat
40. Reversal of levodopa-induced motor fluctuations in experimental parkinsonism by NMDA receptor blockade
41. Techniques to optimize post-embedding single and double staining for amino acid neurotransmitters
42. Time dependence and role of N-methyl-D-aspartate glutamate receptors in the priming of D2-mediated rotational behavior and striatal Fos expression in 6-hydroxydopamine lesioned rats
43. Chronic intracerebral stimulation in Parkinson's disease
44. Evidence that L-dopa-induced rotational behavior is dependent on both striatal and nigral mechanisms
45. Synaptic relationship between dopaminergic afferents and cortical or thalamic input in the sensorimotor territory of the striatum of the monkey
46. 2 balance in the basal ganglia and its relevance to Parkinson's disease
47. Intranigral but not intrastriatal microinjection of the NMDA antagonist MK-801 induces contralateral circling in the 6-OHDA rat model
48. Metabolic activity of the basal ganglia in parkinsonian syndromes in human and non-human primates: A cytochrome oxidase histochemistry study
49. Systemic administration of NMDA and AMPA receptor antagonists reverses the neurochemical changes induced by nigrostriatal denervation in basal ganglia
50. Synaptic activation of N-methyl-D-aspartate receptors induces short-term potentiation at excitatory synapses in the striatum of the rat
51. Modulation of LTP induction by NMDA receptor activation and nitric oxide release