Post-transcriptional effects of interleukin-3, interferon-γ, erythropoietin and butyrate on in vitro hemoglobin chain synthesis in congenital hemolytic anemia

Haematologica

Volumn 86, Issue 8, 2001, Pages 791-800

  Reinhardt, D ^a   Ridder, R ^a   Kugler, W ^a   Pekrun, A ^a  

^a NONE   (Germany)

Author keywords

Cytokines; Hemoglobin synthesis; Hemolyticanemia

Indexed keywords

BUTYRIC ACID; CYTOKINE; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; HEMOGLOBIN CHAIN; HEMOGLOBIN GAMMA CHAIN; INTERLEUKIN 3; LEUCINE; PROTON; RNA; TRANSFERRIN RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; CELL ACTIVITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; HEMOGLOBIN SYNTHESIS; HEMOLYTIC ANEMIA; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RETICULOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RNA STABILITY; TRANSCRIPTION TERMINATION; TRANSLATION REGULATION;

ADOLESCENT; ADULT; ANEMIA, HEMOLYTIC, CONGENITAL; BUTYRATES; CASE-CONTROL STUDIES; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; CYTOKINES; ERYTHROPOIETIN; GLOBINS; HEMOGLOBINS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-3; LEUCINE; MIDDLE AGED; RETICULOCYTES; RNA STABILITY; RNA, MESSENGER; TRITIUM;

EID: 0034858044     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Butyrate in the treatment of sickle cell disease and β-thalassemia
2. Interferon-γ modulates fetal hemoglobin synthesis in sickle cell anemia and thalassemia
3. A short-term trial of butyrate to stimulate fetal-globin-gene expression in the β-globin disorders
4. Butyrate derivatives. New agents for stimulating fetal globin production in the β-globin disorders
5. Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and thalassemia
6. Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells
7. Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53
8. Effect of long-term treatment with recombinant human interleukin-3 in patients with myelodysplastic syndromes
9. In vitro progenitor analysis in a Diamond Blackfan anemia patient who responded once but not twice to interleukin-3 therapy, using short-term and long-term cultures and c-kit analysis
10. Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease
11. Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type 1 cells
12. Induction of soluble IL-2 receptor in patients with myelodysplastic syndromes undergoing high-dose interleukin-3 treatment
13. The role of mRNA stability in the control of globin gene expression
14. Half-lives of β and γ globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes
15. Messenger RNA turnover in cell-free extracts from higher eukaryotes
16. Structural features in the 3′-terminal region of polyribosome-bound rabbit globin messenger RNAs
17. Poly(A), poly(A) binding protein and the regulation of mRNA stability
18. Control of messenger RNA stability in higher eukaryotes
19. Erythroid cell-specific determinants of α-globin mRNA stability
20. A new density gradient system for the separation of human red blood cells
21. Hydroxyurea and hemin affect both the transcriptional and post-transcriptional mechanisms of some globin genes in human adult erythroid cells
22. Cell biology of heme
23. Differential effects of interleukin-3 on fetal and adult erythroid cells in culture: Implications for the isolation of fetal cells from maternal blood
24. Modulation of hemoglobin synthesis in K-562(S) cells treated with interferons
25. Mechanism for fetal hemoglobin induction by hydroxyurea in sickle cell erythroid progenitors
26. Erythropoietin exerts transcriptional and translational control over globin synthesis in J2E cells
27. Cellular and molecular effects of a pulse butyrate regimen and new inducers of globin gene expression and hematopoiesis
28. Induction of globin gene expression in cultured erythroleukemia cells by butyric acid
29. Stimulation of fetal hemoglobin production by short chain fatty acids
30. Fetal hemoglobin induction by acetate, a product of butyrate catabolism
31. A novel approach to investigating the erythroid lineage, using both receptor analysis and haemoglobin detection
32. Specific binding of interferon-γ to high affinity receptors on human erythroid colony-forming cells
33. Erythropoietin receptor characteristics on primary human erythroid cells
34. Globin RNA precursor molecules: Biosynthesis and process in erythroid cells
35. Complementary change in cis determinants and trans factors in the evolution of an mRNP stability complex
36. Erythroid cell-specific mRNA stability elements in the α 2-globin 3′ nontranslated region
37. Nitric oxide alters the expression of γ-globin, H-ferritin, and transferrin receptor in human K562 cells at the post-transcriptional level
38. Hemin-induced acceleration of hemoglobin production in immature cultured erythroid cells: Preferential enhancement of fetal hemoglobin
39. Function and regulation of transferrin and ferritin
40. Interferon γ downregulates stem cell factor and erythropoietin receptors but not insulin-like growth factor-I receptors in human erythroid colony-forming cells
41. Biosynthesis of the transferrin receptor in rabbit reticulocytes
42. An electron-microscope autoradiographic study of transferrin endocytosis by immature erythroid cells
43. Identification and purification of human erythroid progenitor cells by monoclonal antibody to the transferrin receptor (TU 67)
44. Butyrate trials
45. IFN-γ and IL-4 differently regulate inducible NO synthase gene expression through IRF-1 modulation
46. Iron regulatory proteins, iron responsive elements and iron homeostasis
47. Interleukin-2-dependent transcriptional and post-transcriptional regulation of transferrin receptor mRNA
48. Positive modulation of hemoglobin, heme, and transferrin receptor synthesis by murine interferon-α and -β in differentiating friend cells. Pivotal role of heme synthesis
49. Posttranscriptional regulation of transferrin receptor mRNA by IFN γ
50. Cryohemolysis test as a diagnostic tool for hereditary spherocytosis