Ursodeoxycholic acid and in vitro vasoactivity of hydrophobic bile acids

Digestive Diseases and Sciences

Volumn 46, Issue 9, 2001, Pages 2017-2024

  Bomzon, Arieh ^a   Ljubuncic, Predrag ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Bile acids; Lipid peroxidation; Ursodeoxycholic acid; Vascular reactivity

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; BILE ACID; PHENYLEPHRINE; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; URSODEOXYCHOLIC ACID; VASOACTIVE AGENT;

ANIMAL TISSUE; ARTICLE; CHOLESTATIC HEPATITIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; IN VITRO STUDY; LIPID PEROXIDATION; LIPOPHILICITY; MALE; MICROSOME MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; AORTA, ABDOMINAL; BILE ACIDS AND SALTS; CHOLAGOGUES AND CHOLERETICS; LIPID PEROXIDATION; MALE; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, SPRAGUE-DAWLEY; URSODEOXYCHOLIC ACID; VASODILATION;

EID: 0034857084     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010663904820     Document Type: Article

References (35)

1. Bile salts, hypotension and obstructive jaundice
2. Mechanism of bile salt vasoactivity: Dependence on calcium channels in vascular smooth muscle
3. Bile acids as endogenous vasodilators?
4. On the in vitro vasoactivity of bile acids
5. Bile salt stimulation of colonic epithelium proliferation: Evidence for involvement of lipoxygenase products
6. Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes
7. Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids
8. Bile and bile salts potentiate superoxide anion release from activated, rat peritoneal neutrophils
9. Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages
10. Oxidative stress and vascular smooth muscle cell function in liver disease
11. Hepatoprotective properties of ursodeoxycholic acid
12. Pharmacology of ursodeoxycholic acid, an enterohepatic drug
13. Reversible suppression of the vascular contractile response in rats with obstructive jaundice
14. Length-dependent sensitivity in vascular smooth muscle
15. Ursodeoxycholic acid-induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis
16. An improved procedure for the isolation of plasma membranes from rat mesenteric arteries
17. 5′-Nucleotidase
18. Microsomal lipid peroxidation
19. Malondialdehyde determination as an index of lipid peroxidation
20. Protein measurement with the Folin phenol reagent
21. Ursodeoxycholate decreases mitochondrial toxicity and membrane incorporation of lipophilic bile acids
22. Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: A mechanism of UDCA cytoprotection
23. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
24. Ursodeoxycholic acid and endothelial-dependent, nitric oxide-independent vasodilatation of forearm resistance arteries in patients with coronary heart disease
25. A pilot study on the hemodynamic effect of short-term ursodeoxycholic acid therapy in patients with stable liver cirrhosis
26. Effects of ursodeoxycholic acid on splanchnic and systemic hemodynamics - A double-blind, crossover, placebo-controlled study in healthy volunteers
27. The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
28. Cardiac function and responsiveness to β-adrenoceptor agonists in rats with obstructive jaundice
29. Role of lipid peroxidation in biliary obstruction in the rat
30. Cirrhotic cardiomyopathy: Getting to the heart of the matter
31. Jaundice and the kidney
32. Ursodeoxycholic acid suppresses extent of lipid peroxidation in diseased liver in experimental cholestatic liver disease
33. Evidence of a systemic phenomenon for oxidative stress in cholestatic liver disease
34. Reactive oxygen species in living systems: Source, biochemistry, and role in human disease
35. Role of free radicals and catalytic metal ions in human disease: An overview