Mutations in normal breast tissue and breast tumours

Breast Cancer Research

Volumn 3, Issue 5, 2001, Pages 299-303

  Tomlinson, I P M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Genomic instability; Mutation; Selection; Tumorigenesis

Indexed keywords

ALLELE; ARTICLE; BREAST CANCER; BREAST TUMOR; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL DIVISION; CENTROSOME; CLONE; CONTROLLED STUDY; GENE AMPLIFICATION; GENE MUTATION; GENETIC STABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; KARYOTYPE; ONCOGENE; PROBABILITY;

BREAST; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; HUMANS; MUTATION;

EID: 0034855380     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr311     Document Type: Article

References (17)

1. Loss of heterozygosity in normal tissue adjacent to breast carcinomas
2. A genetic model for colorectal tumorigenesis
3. Genetic alterations in 'normal' luminal and myoepithelial cells of the breast
4. The clonal origin and clonal evolution of epithelial tumours
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6. How many mutations does it take to make a tumor?
7. A mutator phenotype in cancer
8. The clonal nature of neoplasia
9. The mutation rate and cancer
10. Genetic instability and darwinian selection in tumours
11. Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog
12. Mutations in the APC tumour suppressor gene cause chromosomal instability
13. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines
14. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
15. Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers
16. Microsatellite instability markers in breast cancer: A review and study showing MSI was not detected at 'BAT 25' and 'BAT 26' microsatellite markers in early-onset breast cancer
17. Low frequency of microsatellite instability in sporadic breast cancer