No evidence for diabetes-associated mutations of PEK/EIF2AK3 gene in French patients with early-onset type II diabetes [4]

Diabetologia

Volumn 44, Issue 6, 2001, Pages 786-

  Vaxillaire, M ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 2ALPHA KINASE 3; PROTEIN KINASE; UNCLASSIFIED DRUG;

FRANCE; GENE MUTATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GLUCOSE INTOLERANCE; HUMAN; LETTER; NON INSULIN DEPENDENT DIABETES MELLITUS; ONSET AGE; PRIORITY JOURNAL;

AGE OF ONSET; DIABETES MELLITUS, TYPE 2; EIF-2 KINASE; HUMANS; MUTATION;

EID: 0034853090     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051690     Document Type: Letter

References (7)

1. Wolcott-Rallison syndrome: Diabetes mellitus and spondyloepiphyseal dysplasia
2. EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome
3. PKR, a sentinel kinase for cellular stress
4. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
5. Characterization of a mutant pancreatic eIF-2-alpha kinase, PEK, and co-localization with somatostatin in islet delta cells
6. Perk is essential for translational regulation and cell survival during the unfolded protein response
7. Mutation screening in 18 Caucasian families suggest the existence of other MODY genes