Extending preclinical models of skeletal manifestations of malignancy to the clinical setting

Seminars in Oncology

Volumn 28, Issue 4 SUPPL. 11, 2001, Pages 9-14

  Goltzman, David ^a,b  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; GROWTH FACTOR; PARATHYROID HORMONE RELATED PROTEIN; SEOCALCITOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; BONE DEVELOPMENT; BONE METASTASIS; CONFERENCE PAPER; CONTROLLED STUDY; HYPERCALCEMIA; HYPOPHOSPHATEMIA; MOUSE; NONHUMAN; OSTEOLYSIS; OSTEOMALACIA; OSTEOPENIA; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN SYNTHESIS; RAT;

EID: 0034852865     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/sonc.2001.25430     Document Type: Conference Paper

References (16)

1. Uses and abuses of bisphosphonates
2. Molecular basis of the spectrum of skeletal complications of neoplasia
3. Effects of synthetic vitamin D analogs on breast cancer cell proliferation in vivo and in vitro
4. EB1089: A novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells
5. Effects of a new synthetic vitamin D analogue, EB 1089, on the oestrogen responsive growth of human breast cancer cells
6. EB1089, a novel vitamin D analog with strong antiproliferative and differentiation-inducing effects on targets cells
7. Induction of parathyroid hormone-related peptide by the ras-oncogene: Role of ras farnesylation inhibitors as potential therapeutic agents for hypercalcemia of malignancy
8. A vitamin D analogue (EB1089) inhibits parathyroid hormone-related peptide production and prevents the development of malignancyassociated hypercalcemia in vivo
9. Reversal of hypercalcemia with the vitamin D analogue EB 1089 in a human model of squamous cancer
10. The clinical course of bone metastases from breast cancer
11. Localization of parathyroid hormone-related protein in breast cancer metastasis: Increased incidence in bone compared with other sites
12. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis
13. Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice
14. The vitamin D analogue EB 1089 prevents skeletal metastasis and prolongs survival time in nude mice transplanted with human breast cancer cells
15. Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo
16. Cloning of human PEX cDNA. Expression, subcellular localization, and endopeptidase activity