Morphological examination of the effects of defibrotide on experimentally induced bladder injury and its relation to interstitial cystitis

Urological Research

Volumn 29, Issue 4, 2001, Pages 263-271

  Aydin, H ^a   Ercan, F ^a   Cetinel S ^a   San, T ^a  

^a MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Defibrotide; Interstitial cystitis; Protamine sulfate; Ultrastructure; Urinary bladder

Indexed keywords

DEFIBROTIDE; GLYCOSAMINOGLYCAN; PROTAMINE SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER INJURY; CELL JUNCTION; CONTROLLED STUDY; DRUG EFFECT; ELECTRON MICROSCOPY; FEMALE; INTERSTITIAL CYSTITIS; MAST CELL; MICROVILLUS; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; TIGHT JUNCTION; UROTHELIUM;

ANIMALS; CYSTITIS, INTERSTITIAL; CYTOPROTECTION; FEMALE; MAST CELLS; POLYDEOXYRIBONUCLEOTIDES; PROTAMINES; RATS; RATS, WISTAR; URINARY BLADDER; URINARY BLADDER DISEASES;

EID: 0034852468     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002400100196     Document Type: Article

References (50)

1. Scanning electron microscopic findings in interstitial cystitis
2. The role of defibrotide on experimentally induced bladder injury
3. Enhancement by defibrotide of prostanoid neosynthesis from arachidonic acid: An adenosine receptor-mediated effect
4. Morphological changes in carotid arteries of rabbits induced by defibrotide infusion
5. Nerve fiber proliferation in interstitial cystitis
6. In vitro inhibition by defibrotide of monocyte superoxide anion generation: A possible mechanism for the antithrombotic effect of a polydeoxyribonucleotide-derived drug
7. Acute effects of defibrotide, an experimental antithrombotic agent, on fibrinolysis and blood prostenoids in man
8. Possible role of defibrotide in endothelial cell protection
9. Effect of defibrotide on polymorphonuclear leucocytes: Modulation of calcium entry and availability
10. Usefulness of defibrotide in the treatment of vascular disorders: A clinical-pharmacologic logic study
11. Defibrotide inhibits calcium dependent neutrophil activation: Implications for its pharmacological activity in vascular disorders
12. Electron microscopic investigation of the bladder urothelium and glycocalyx in patients with interstitial cystitis
13. Permeability and ultrastructure of human bladder epithelium
14. The effects of cold-restraint stress on urinary bladder wall compared with interstitial cystitis morphology
15. Effects of defibrotide on stress-induced bladder morphology
16. Role of afferent neurons in stress induced degenerative changes of the bladder
17. A clinicopathological and virological study of interstitial cystitis
18. Immunosuppressive effects of defibrotide
19. Peptides in neurogenetic inflammation
20. Interstitial cystitis is associated with intraurothelial Tamm-Horsfall protein
21. Interstitial cystitis or reflex sympathetic dystrophy of the bladder
22. Interstitial and haemorrhagic cystitis: Viral, bacterial, fungal studies
23. Heparin protects cultured arterial endothelial cells from damage by toxic oxygen metabolites
24. Analysis of structural properties of the urinary bladder: The impact of the SEM and ancillary approaches. Cells and tissues: A three dimensional approach by modern techniques in microscopy
25. Protamine a review of its toxicity
26. Pathology of interstitial cystitis
27. Coronary endothelium-protective effects of defibrotide in ischaemia and reperfusion
28. Bladder surface glycosaminoglycans. Is a human epithelial permeability barrier?
29. Novel beneficial mechanisms of defibrotide, a prostacyclin enhancing agent in splanchnic artery occlusion and reperfusion in rats
30. Protection of kidney from postischaemic reperfusion injury in rats treated with defibrotide
31. A new method for cytodestruction of bladder epithelium using protamine sulfate and urea
32. Defibrotide a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in vascular disorders
33. Bladder surface glycosaminoglycans: An efficient mechanism of environmental adaptation
34. Bladder surface glycosaminoglycans: An epithelial permeability barrier
35. Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis)
36. Treatment of interstitial cystitis with intravesical heparin
37. Protamine interaction with the epithelial cell surface
38. A role for anionic sites in epithelial architecture
39. Effects of defibrotide on renal function and urinary prostanoid excretion in cyclosporin-treated rats
40. Activation of endothelial cells
41. Are increased ATP blood levels responsible for PGI2 release from endothelium?
42. Protective effect of defibrotide on perfusion induced endothelial damage
43. Diagnosis of IC: A clinical endoscopic and pathology approach
44. Heparin prevents postischemic endothelial cell dysfunction by a mechanism inndependent of its anticoagulant activity
45. Effects of protamine, heparinase, and hyaluranidase on endothelial permeability and surface charge
46. Activation of bladder mast cells in interstitial cystitis: A light and electron microscopic study
47. Effect of protamine sulfate on the permeability properties of the mammalian bladder
48. Antithrombotic effect and clinical potential of defibrotide