Metabolism of GS-7340, a novel phenyl monophosphoramidate intracellular prodrug of PMPA, in blood

Nucleosides, Nucleotides and Nucleic Acids

Volumn 20, Issue 4-7, 2001, Pages 1091-1098

  Eisenberg, E J ^a   He, G X ^a   Lee, W A ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 [2 [[[[1 (ISOPROPOXYCARBONYL)ETHYL]AMINO]PHENOXYPHOSPHINYL]METHOXY]PROPYL]ADENINE; ACYCLIC NUCLEOSIDE PHOSPHONATE; DRUG METABOLITE; GS 7340; PHENYL PHOSPHORAMIDATE; PHOSPHONIC ACID DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHOTRANSFERASE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; BLOOD; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; ERYTHROCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INCUBATION TIME; MONONUCLEAR CELL; NONHUMAN; PHOSPHORYLATION;

ADENINE; ANIMALS; ANTI-HIV AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HUMANS; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PRODRUGS;

ANIMALIA; CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0034852392     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-100002496     Document Type: Conference Paper

References (3)

1. Acyclic purine nucleoside phosphonates as retrovirus inhibitors
2. Safety, pharmacokinetics and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy) propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults
3. Anti-HIV activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxy-propyl) adenine (PMPA), bis (isopropyloxymethylcarbonyl) PMPA