Purification of PMPA amidate prodrugs by SMB chromatography and x-ray crystallography of the diastereomerically pure GS-7340

Nucleosides, Nucleotides and Nucleic Acids

Volumn 20, Issue 4-7, 2001, Pages 1085-1090

  Chapman, H ^a   Kernan, M ^a   Rohloff, J ^a   Sparacino, M ^a   Terhorst, T ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GS 7340; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; TENOFOVIR; UNCLASSIFIED DRUG;

CHIRALITY; CHROMATOGRAPHY; CONFERENCE PAPER; CRYSTAL STRUCTURE; DIASTEREOISOMER; DRUG BIOAVAILABILITY; DRUG PURIFICATION; DRUG STRUCTURE; X RAY CRYSTALLOGRAPHY;

ADENINE; ANTI-HIV AGENTS; CHROMATOGRAPHY; CRYSTALLOGRAPHY, X-RAY; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PRODRUGS; STEREOISOMERISM;

EID: 0034852391     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-100002495     Document Type: Article

References (5)

1. Practical syntheses, separation and stereochemical assignment of the PMPA pro-drug, GS-7340
2. Comparison of batch elution chromatography and continuous simulated moving bed chromatography