Relationship between lactone ring forms of HCPT and their antitumor activities

Acta Pharmacologica Sinica

Volumn 22, Issue 9, 2001, Pages 827-830

  Zhou, J J ^a   Liu, J ^a   Xu, B ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

10 hydroxycamptothecin; Antineoplastic agents; Cell culture; High pressure liquid chromatography; Lactones

Indexed keywords

10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; LACTONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CULTURE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; NONHUMAN; SARCOMA;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; LACTONES; LIVER NEOPLASMS; MICE; SARCOMA 180; TUMOR CELLS, CULTURED;

EID: 0034849504     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Hydroxycamptothecin as an antitumor agent
2. Plant antitumor agents. 18' Synthesis and biological activity of camptothecin
3. Alkaloids with antitumor activiting
4. Studies of the sensitivity of several tumour models in screen of anticancer agents
5. Improved MTT assay for activity of antitumor agents
6. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
7. Determination of camptothecin by HPLC method
8. Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and a relation to antitumor activity
9. Modification of the hydroxy lactone ring of camptothecin: Inhibition of mammalian topoisomerase I and biological activity