Increased platelet-derived growth factor (PDGF) release after laparotomy stimulates systemic tumor growth in mice

Surgical Endoscopy

Volumn 15, Issue 9, 2001, Pages 981-985

  Lee, S W ^a   Gleason, N R ^a   Stapleton, G S ^a   Zhai, C ^a   Huang, E H ^a   Bessler, M ^a   Whelan, R L ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Laparotomy; PDGF; Plasma soluble factor; Platelet derived growth factor; Tumor

Indexed keywords

HEPARIN BINDING PROTEIN; NEUTRALIZING ANTIBODY; PLATELET DERIVED GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL PROLIFERATION; CHROMATOGRAPHY; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; LAPAROTOMY; MITOGENESIS; MOUSE; NONHUMAN; PNEUMOPERITONEUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; STATISTICAL ANALYSIS; TUMOR GROWTH;

ADENOCARCINOMA; ANIMALS; CELL DIVISION; COLONIC NEOPLASMS; FEMALE; GROWTH SUBSTANCES; LAPAROTOMY; MICE; MICE, INBRED BALB C; PLATELET-DERIVED GROWTH FACTOR; TUMOR CELLS, CULTURED;

EID: 0034847949     PISSN: 09302794     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004640080012     Document Type: Conference Paper

References (9)

1. Tumor growth after laparoscopy and laparotomy in a murine model
2. Better preservation of immune function after laparoscopic-assisted vs. open bowel resection in a murine model
3. Differences in tumor growth after open versus laparoscopic surgery are lost in an athymic model and are associated with differences in tumor proliferative index
4. Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth
5. A serum soluble factor(s) stimulates tumor growth following laparotomy in a murine model
6. 2 pneumoperitoneum
7. A significant part of macrophage derived growth factor consists of at least two forms of PDGF
8. Platelet-derived growth factor AA homodimer is the predominant isoform in human platelets and acute human wound fluid
9. Colon adenocarcinoma and B-16 melanoma grow larger following laparotomy vs. pneumoperitoneum in a murine model