GnRH agonists and antagonists stimulate recovery of fertility in irradiated LBNF1 rats

Journal of Andrology

Volumn 22, Issue 5, 2001, Pages 809-817

  Meistrich, M L ^a   Wilson, G ^a   Shuttlesworth, G ^a   Huhtaniemi, I ^a   Reissmann, T ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Leydig cells; Luteinizing hormone; Spermatogenesis; Testosterone; Toxicology

Indexed keywords

CETRORELIX; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; LEUPRORELIN;

ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; LEYDIG CELL; MALE; MALE INFERTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPERMATOGENESIS; SPERMATOZOON COUNT;

ANIMALS; FEMALE; FERTILITY; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; LEUPROLIDE; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPERMATOGENESIS; TESTOSTERONE;

EID: 0034845254     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Highly potent antagonists of luteinizing hormone-releasing hormone free of edematogenic effects
2. Gonadotropin-releasing hormone and its agonist inhibit testicular luteinizing hormone receptor and steroidogenesis in immature and adult hypophysectomized rats
3. In vivo and in vitro investigation of the extrapituitary antireproductive effects of a potent LHRH agonist in immature and adult male rats
4. 2, 5-Hexanedione exposure in the rat results in long-term testicular atrophy despite the presence of residual spermatogonia
5. Direct inhibition of testicular function by gonadotropin-releasing hormone: Mediation by specific gonadotropin-releasing hormone receptors in interstitial cells
6. Endocrine regulation and communicating functions of the Leydig cell
7. A supersensitive immunofluorometric assay for rat luteinizing hormone
8. Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix
9. Blockade of rat testicular gonadotropin releasing hormone (GnRH) receptors by infusion of a GnRH antagonist has no major effects of Leydig cell function in vivo
10. Effect of treatment with GnRH antagonist, GnRH antiserum and bromocriptine on pituitary-testicular function of adult rats
11. 1 rat
12. Recovery from severe oligospermia after exposure to dibromochloropropane
13. Restoration of spermatogenesis by hormone treatment after cytotoxic therapy
14. Hormone treatment after irradiation stimulates recovery of rat spermatogenesis from surviving spermatogonia
15. Spermatogonial stem cells: Assessing their survival and ability to produce differentiated cells
16. Impact of cyclophosphamide on long-term reduction in sperm count in men treated with combination chemotherapy for Ewing's and soft tissue sarcomas
17. Hormonal treatment after cytotoxic therapy stimulates recovery of spermatogenesis
18. Controlled release of LHRH agonist, leuprolide acetate, from microcapsules: Serum drug level profiles and pharmacological effects in animals
19. One-month release injectable microspheres of leuprolide acetate inhibit steroidogenesis and genital organ growth in rats
20. Pharmacokinetics of once-a-month injectable microspheres of leuprolide acetate
21. 1 hybrid rats
22. Pharmacological studies with Cetrorelix (SB-75), a potent antagonist of luteinizing hormone-releasing hormone
23. Effect of graded doses of ionizing radiation on the human testis
24. Gonadotropin-releasing hormone analogs stimulate and testosterone inhibits the recovery of spermatogenesis in irradiated rats
25. Enhancement of a spermatogonial proliferation and differentiation in irradiated rats by GnRH antagonist administration
26. GnRH-mediated desensitization of the pituitary gonadotrope is not calcium dependent
27. Hormone pretreatment enhances recovery of spermatogenesis in rats after neutron irradiation