Role of disease-causing genes in sporadic pancreatic endocrine tumors: MEN1 and VHL

Genes Chromosomes and Cancer

Volumn 32, Issue 2, 2001, Pages 177-181

  Moore, Patrick S ^a   Missiaglia, Edoardo ^a   Antonello, Davide ^a   Zamó, Alberto ^a   Zamboni, Giuseppe ^a   Corleto, Vito ^b   Falconi, Massimo ^a   Scarpa, Aldo ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CHROMOSOME 11Q; ENDOCRINE TUMOR; GENE MUTATION; GERM LINE; HUMAN; HUMAN TISSUE; INSULINOMA; MULTIPLE ENDOCRINE NEOPLASIA; PANCREAS; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE; VIPOMA; VON HIPPEL LINDAU DISEASE;

EID: 0034843771     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1180     Document Type: Article

References (28)

1. Chromosome 7q allelic losses in pancreatic carcinoma
2. Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors
3. Pancreatic endocrine tumours: Evidence for a tumour suppressor pathogenesis and for a tumour suppressor gene on chromosome 17p
4. VHL alterations in human clear cell renal cell carcinoma: Association with advanced tumor stage and a novel hot spot mutation
5. Revised classification of neuroendocrine turnouts of the lung, pancreas and gut
6. Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13
7. Positional cloning of the gene for multiple endocrine neoplasia-type 1
8. A novel pancreatic endocrine tumor suppressor gene locus on chromosome 3p with clinical prognostic implications
9. Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors
10. Lack of MEN1 gene mutations in 27 sporadic insulinomas
11. Putative tumor-suppressor gene on chromosome 11 is important in sporadic endocrine tumor formation
12. Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: Evidence for solvent-induced bends in DNA hetetoduplexes
13. Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders
14. Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms
15. MEN1 gene mutation analysis of sporadic adrenocortical lesions
16. Mutation of the multiple endocrine neoplasia type I gene in nonfamilial, malignant tumors of the endocrine pancreas
17. Identification of the von Hippel-Lindau disease tumor suppressor gene
18. Multiple endocrine neoplasia type 1: Clinical features and managment
19. Pancreatic tumors: Molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis
20. Molecular characterization of pancreatic serous microcystic adenomas: Evidence for a tumor suppressor gene on chromosome 10q
21. Genetic alterations in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors: An analysis of p16/MTS1 tumor suppressor gene inactivation
22. Endocrine tumors of the pancreas: Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy: A comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinicopathologic variables
23. Molecular features of primary mediastinal B-cell lymphoma: Involvement of p16INK4A, p53 and c-myc
24. Cancer of the ampulla of Vater: Chromosome 17p allelic loss is associated with poor prognosis
25. Somatic mutations of multiple endocrine neoplasia type 1 gene in the sporadic endocrine tumors
26. Mutation of the MENIN gene in sporadic pancreatic endocrine tumors
27. Multiple endocrine adenomatosis: Multiple hormone-producing tumours, a family syndrome
28. Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas