The nature of the bond between peptide and carrier molecule determines the immunogenicity of the construct

Journal of Peptide Research

Volumn 58, Issue 3, 2001, Pages 237-245

  Beekman, N J C M ^a,b   Schaaper, W M M ^a   Langeveld, J P M ^a   Boshuizen, R S ^a   Meloen, R H ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Carrier molecule; Immunogenicity; Labile bond; Lipo peptide; Palmitic acid; Thioester; Vaccine

Indexed keywords

AMIDE; LIPID; LIPOPEPTIDE; PALMITIC ACID; PEPTIDE; THIOESTER; VACCINE;

ADOLESCENT; AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; COVALENT BOND; DEGRADATION; DISULFIDE BOND; FEMALE; IMMUNIZATION; IMMUNOGENICITY; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE;

AMIDES; ANIMALS; ANTIBODIES; DISULFIDES; DRUG CARRIERS; FEMALE; FOOT-AND-MOUTH DISEASE VIRUS; GONADOTROPIN-RELEASING HORMONE; GUINEA PIGS; HYDROCARBONS; MALE; MODELS, CHEMICAL; PALMITIC ACID; PARVOVIRUS, CANINE; PEPTIDES; SULFIDES; SWINE; VACCINES, SUBUNIT;

ANIMALIA; SUS SCROFA;

EID: 0034841118     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2001.00905.x     Document Type: Article

References (21)

1. Protein lipidation in cell signaling
2. Immunogenicity of a synthetic HBsAg peptide: Enhancement by conjugation to a fatty acid carrier
3. Palmitic acid conjugation of a protein antigen enhances major histocompatibility complex class II-restricted presentation to T cells
4. A novel chemical approach to drug delivery: Lipidic amino acid conjugates
5. Activation and depalmitoylation of Gs alpha
6. Palmitoyl-thioester peptides as vaccines: Highly immunogenic and easy to synthesize
7. Organic synthesis and biological signal transduction
8. Synthesis of palmitoyl-thioester T-cell epitopes of myeline proteolipid protein (PLP). Comparison of two thiol-protecting groups (StBu and Mmt) for on-resin acylation
9. Polarity of immunogens: Implications for vaccine design
10. The immune response of haptenic peptides is dictated by the specific attachment position and carrier protein
11. Novel low-molecular-weight synthetic vaccine against foot-and-mouth disease containing a potent B-cell and macrophage activator
12. Soluble proteins incorporate into ISCOMs after covalent attachment of fatty acid
13. Synthetic peptide vaccines: Palmitoylation of peptide antigens by a thioester bond increases immunogenicity
14. Effective induction of neutralizing antibodies with the amino terminus of VP2 of canine parvovirus as a synthetic peptide
15. Full protection in mink against mink enteritis virus with new generation canine parvoviruses based on synthetic peptide or recombinant protein
16. Efficient immunocastration of male piglets by immunoneutralization of GnRH using a new GnRH-like peptide
17. Testis size after immunocastration as parameter for the absence of boar taint
18. New GnRH-like peptide construct to optimize efficient immunocastration of male pigs by immunoneutralization of GnRH
19. Synthetic peptides derived from the β2-β3 loop of Raphanus sativus antifungal protein 2 that mimic the active site
20. HBTU activation for automated Fmoc solid phase peptide synthesis
21. Disulfide bond formation in peptides by dimethyl sulfoxide. Scope and applications