Effects of transforming growth factors-α and -β on proliferation and apoptosis of rat theca-interstitial cells

Journal of Endocrinology

Volumn 170, Issue 3, 2001, Pages 639-645

  Pehlivan, T ^a   Mansour, A ^a   Spaczynski, R Z ^a   Duleba, A J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYADENOSINE TRIPHOSPHATE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; DNA; DNA FRAGMENT; PHOSPHORUS 32; THYMIDINE; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRITIUM;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASSAY; CELL COUNT; CELL CULTURE; CELL DEATH; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE ASSOCIATION; DNA CLEAVAGE; DNA SYNTHESIS; DOSE RESPONSE; DRUG POTENTIATION; ENZYME ACTIVITY; FEMALE; HISTOCHEMISTRY; HOMEOSTASIS; IMMATURITY; INCUBATION TIME; LEYDIG CELL; MESENCHYME; MOLECULAR WEIGHT; NONHUMAN; NUCLEOSOME; OVARY CELL; OVARY DEVELOPMENT; OVARY FOLLICLE ATRESIA; OVARY FOLLICLE DEVELOPMENT; OVARY POLYCYSTIC DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PURIFICATION; RAT STRAIN; THECA CELL;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL DIVISION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; RATS; RATS, SPRAGUE-DAWLEY; THECA CELLS; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034836891     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1700639     Document Type: Article

References (52)

1. Intrafollicular insulin-like growth factor-II levels in normally ovulating women and in patients with polycystic ovary syndrome
2. Epidermal growth factor influences growth and differentiation of rat granulosa cells
3. The modulation of gonadotrophic hormone action on the ovary by paracrine and autocrine factors
4. Neonatal estrogen exposure alters the transforming growth factor-beta signaling system in the developing rat prostate and blocks the transient p21 (cip1/waf1) expression associated with epithelial differentiation
5. Presence of transforming growth factor-beta and their selective cellular localization in human ovarian tissue of various reproductive stages
6. Immunocytochemical localization of transforming growth factors (TGFs) TGF-alpha and TGF-beta in human ovarian tissues
7. Systemic treatment in the rat with epidermal growth factor causes polycystic growth of the ovaries
8. Transforming growth factor-beta (TGF-beta)
9. Hormonal regulation of type I receptor tyrosine kinase expression in the mammary gland
10. Transforming growth factor beta and follicle-stimulating hormone promote rat granulosa cell proliferation
11. Effects of insulin and insulin-like growth factors on proliferation of rat ovarian theca-interstitial cells
12. Induction of apoptosis in rat thecal/interstitial cells by transforming growth factor alpha plus transforming growth factor beta in vitro
13. Induction of apoptosis in thecal/interstitial cells: Action of transforming growth factor (TGF) alpha plus TGF beta on bcl-2 and interleukin-1 beta-converting enzyme
14. Transforming growth factor-beta inhibits ovarian 17 alpha-hydroxylase activity by a direct noncompetitive mechanism
15. TGF-beta cooperates with TGF-alpha to induce the self-renewal of normal erythrocytic progenitors: Evidence for an autocrine mechanism
16. The production of transforming growth factor-beta in the porcine ovary and its secretion in vitro
17. Fibroblast and epidermal growth factors are mitogenic agents for cultured granulosa cells of rodent, porcine, and human origin
18. Human transforming growth factor-beta 3: Recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2
19. Isolation of high-molecular-weight DNA from mammalian cells
20. Interaction of estrogen and gonadotrophins on follicular atresia
21. Transforming growth factor-beta 1 inhibits ovarian androgen production: Gene expression, cellular localization, mechanisms(s), and site(s) of action
22. Ovarian follicle atresia: A hormonally controlled apoptotic process
23. Ovarian follicular atresia as an apoptotic process: A paradigm for programmed cell death in endocrine tissues
24. Ovarian intrabursal administration of transforming growth factor beta 1 inhibits follicle rupture in gonadotropin-primed mice
25. Ovarian transforming growth factor-alpha gene expression: Immunohistochemical localization to the theca-interstitial cells
26. TM-1 cells from an established human malignant glioma cell line produce PDGF, TGF-alpha, and TGF-beta which cooperatively play a stimulatory role for an autocrine growth promotion
27. Estrogen treatment of immature rats inhibits ovarian androgen production in vitro
28. Induction of follicle-stimulating hormone (FSH) receptors in rat ovaries by estrogen priming
29. The effects of growth factors and phorbol esters on steroid biosynthesis in isolated human theca interna and granulosa-lutein cells in long term culture
30. Growth factors in human ovarian follicle fluid and growth factor receptors in granulosa-luteal cells
31. Estradiol-17 beta, insulin-like growth factor-I, and luteinizing hormone inhibit secretion of transforming growth factor beta by rat ovarian theca-interstitial cells
32. Production of transforming growth factor-alpha by normal and polycystic ovaries
33. Epidermal growth factor-like transforming growth factor. I. Isolation, chemical characterization, and potentiation by other transforming factors from feline sarcoma virus-transformed rat cells
34. Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation
35. Rat thecal/interstitial cells express transforming growth factor-beta type 1 and 2, but only type 2 is regulated by gonadotropin in vitro
36. Effects of transforming growth factor alpha and beta on rabbit gastric epithelial cell proliferation: A preliminary report
37. The expression of transforming growth factor alpha receptor protein and its activation in chicken ovarian granulosa cells of maturing follicles
38. Immunohistochemical localization of epidermal growth factor receptors, epidermal-growth-factor-like and transforming-growth-factor-alpha-like peptides in chicken ovarian follicles
39. Regulation of cell proliferation and estrogen synthesis by ovine LH, IGF-I, and EGF in theca interstitial cells of the domestic hen cultured in defined media
40. Expression of receptors for insulin-like growth factor-I and transforming growth factor-beta in human follicles
41. Transforming growth factor-alpha and -beta differentially regulate growth and steroidogenesis of bovine thecal cells during antral follicle development
42. Ovarian transforming growth factor-beta (TGF-beta) receptors: In-vitro effects of follicle stimulating hormone, epidermal growth factor and TGF-beta on receptor expression in human preantral follicles
43. Identification of an estrogen-mediated deoxyribonucleic acid-binding independent transactivation pathway on the epidermal growth factor receptor gene promoter
44. Expression of TGF-beta s and TGF-beta type II receptor mRNAs in mouse folliculogenesis: Stored maternal TGF-beta 2 message in oocytes
45. Immunoreactivity of antibodies to epidermal growth factor, transforming growth factors alpha and beta, and epidermal growth factor receptor in the premenopausal ovary
46. Regulation of ovarian cell growth through the local production of transforming growth factor-alpha by theca cells
47. Ovarian thecal cells produce transforming growth factor-beta which can regulate granulosa cell growth
48. Synthesis of biologically active rat transforming growth factor I
49. Localization of epidermal growth factor (EGF) receptor in the rat corpus luteum, and EGF and transforming growth factor-alpha stimulation of luteal cell steroidogenesis in vitro
50. Involvement of apoptosis in ovarian follicular atresia and postovulatory regression
51. Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism
52. Follicular fluid steroid and epidermal growth factor content, and in vitro estrogen release by granulosa-luteal cells from patients with polycystic ovaries in an IVF/ET program