Cisplatin exposure induces mitochondrial toxicity in pregnant rats and their fetuses

Reproductive Toxicology

Volumn 15, Issue 5, 2001, Pages 525-531

  Gerschenson, Mariana ^a,c   Paik, Catherine Y ^a   Gaukler, Emily L ^a   Diwan, Bhalchandra A ^b   Poirier, Miriam C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

cis Diamminedicholorplatinum(11); DNA; DNA adduct; Electron microscopy; Fetus; Mitochondria; Oxidative phosphorylation; Perinatal

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

AGED; ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DNA ADDUCT; DNA CONTENT; DRUG EFFECT; ELECTRON MICROSCOPY; EMBRYOLOGY; ENZYME ACTIVITY; ENZYMOLOGY; FEMALE; FETUS; FETUS DEVELOPMENT; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LIVER; LIVER MITOCHONDRION; MITOCHONDRIAL RESPIRATION; NONHUMAN; OVARY CANCER; OXIDATIVE PHOSPHORYLATION; PREGNANCY; PRENATAL EXPOSURE; RAT; RAT STRAIN; ULTRASTRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN; CISPLATIN; DNA, MITOCHONDRIAL; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; INJECTIONS, INTRAPERITONEAL; KIDNEY; LIVER; MICROSCOPY, ELECTRON; MITOCHONDRIA, LIVER; OXIDATIVE PHOSPHORYLATION; PREGNANCY; RATS; RATS, INBRED F344;

EID: 0034835686     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(01)00156-3     Document Type: Article

References (35)

1. Gynecologic tumors
2. Is cisplatin a human carcinogen?
3. Delivery of a normal infant following cisplatin, vinblastine, and bleomycin (PVB) chemotherapy for malignant teratoma of the ovary during pregnancy
4. Cis-platinum combination chemotherapy during pregnancy for advanced epithelial ovarian carcinoma
5. Transplacental cisplatin exposure induces persistent fetal mitochondrial and genomic DNA damage in patas monkeys
6. DNA adducts in human, and patas monkey maternal, and fetal tissues induced by platinum drug chemotherapy
7. Transplacental carcinogenesis by cisplatin in F344/NCr rats: Promotion of kidney tumors by postnatal administration of sodium barbital
8. Cisplatin-DNA adduct formation in maternal, and fetal rat tissues after transplacental cisplatin exposure
9. Elevated mitochondrial cisplatin-DNA adduct levels in rat tissues after transplacental cisplatin exposure
10. Cisplatin nephrotoxicity. A review
11. Toxic effects of cis-dichlorodiammineplatinum(II) in man
12. Cis-diamminedichlorplatinum-induced acute renal failure in the rat
13. Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations
14. A possible cellular mechanism of cisplatin-induced nephrotoxicity
15. Mitochondrial injury: An early event in cisplatin toxicity to renal proximal tubules
16. Cisplatin nephrotoxicity: Decreases in mitochondrial protein sulphydryl concentration and calcium uptake by mitochondria from rat renal cortical slices
17. Critical subcellular targets of cisplatin and related platinum analogs in rat renal proximal tubule cells
18. Changes in serum, liver and kidneys of cisplatin-treated rats; effects of antioxidants
19. Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: Mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain
20. Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3′-azido-3′-deoxythymidine (AZT)
21. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
22. Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts and transmitochondrial cell lines
23. Levels of mitochondrial endonuclease during rat cardiac development implicate a role for the enzyme in repair of oxidative damage in mitochondrial DNA
24. Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse
25. Mitochondrial oxidative phosphorylation thermodynamic efficiencies reflect physiological organ roles
26. Preferential formation and decreased removal of cisplatin-DNA adducts in Chinese hamster ovary cell mitochondrial DNA as compared to nuclear DNA
27. Preferential binding of cisplatin to mitochondrial DNA and suppression of ATP generation in human malignant melanoma cells
28. Differential effects of cisplatin on mouse hepatic and renal mitochondrial DNA
29. Cisplatin-DNA adduct determination in the hepatic albumin gene as compared to whole genomic DNA
30. Mitochondrial DNA maintenance in vertebrates
31. Energetic characteristics of cisplatin resistant ovarian carcinoma cells
32. Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin
33. Cisplatin induced intermediate filament reorganization and altered mitochondrial function in 3T3 cells and drug-sensitive and -resistant walker 256 cells
34. Increased sensitivity to cis-diamminedichloroplatinum induced apoptosis with mitochondrial DNA depletion