Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line

Fundamental and Clinical Pharmacology

Volumn 15, Issue 3, 2001, Pages 201-207

  Lavička, Juraj ^a   Šarišský, Marek ^a   Miroššay, Andrej ^a   Šulla, Igor ^a   Mojziš, Ján ^a   Mirossay, Ladislav ^a  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

Author keywords

Cytotoxicity; Diazepam; Etoposide; U 87 MG cell line

Indexed keywords

ANTINEOPLASTIC AGENT; BENZODIAZEPINE RECEPTOR; DIAZEPAM; ETOPOSIDE; LIGAND;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; INCUBATION TIME; PRIORITY JOURNAL;

ANTICONVULSANTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; DIAZEPAM; DRUG INTERACTIONS; DRUG SCREENING ASSAYS, ANTITUMOR; ETOPOSIDE; GLIOMA; HUMANS; TUMOR CELLS, CULTURED;

EID: 0034835357     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1472-8206.2001.00030.x     Document Type: Article

References (31)

1. Primary brain tumors, review of etiology, diagnosis, and treatment
2. Chemotherapy for gliomas
3. Wild-type p53-dependent etoposide-induced apoptosis mediated by caspase-3 activation in human glioma cells
4. Cell death induced by topoisomerase-targeted drugs more questions than answers
5. Chemotherapy-induced apoptosis
6. Expression of peripheral-type benzodiazepine receptor diazepam binding inhibitor in human astrocytomas: Relationship to cell proliferation
7. Expression of mitochondrial benzodiazepine receptor and its putative endogenous ligand diazepam binding inhibitor in cultured primary astrocytes C-6 cells: Relation to cell growth
8. A new aspect of the antiproliferative action of peripheral-type benzodiazepine receptor ligands
9. Inhibition of growth factor-induced DNA synthesis in astrocytes by ligands of peripheral-type benzodiazepine receptors
10. Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine receptor
11. Potentiation of lonidamine, diazepam two agents acting on mitochondria in human glioblastoma treatment
12. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis reverse Bcl-2-mediated cytoprotection
13. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition
14. Benzodiazepines that bind at peripheral sites inhibit cell proliferation
15. Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro
16. Antiproliferative differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells
17. Peripheral-type benzodiazepine receptors in the regulation of proliferation of MCF-7 human breast carcinoma cell line
18. Differentiation of friend erythroleukaemia cells induced by benzodiazepines
19. Diazepam induces mitotic arrest at prometaphase by inhibiting centriolar separation
20. 3H] diazepam binding in mammalian central nervous sytem: A pharmacological characterization
21. Stimulation of growth and DNA synthesis by peripheral benzodiazepine
22. Mitochondrial benzodiazepine receptors the regulation of steroid biosynthesis
23. Imaging of a glioma using peripheral benzodiazepine receptor ligands
24. Increase in omega 3 (peripheral-type benzodiazepine) binding site densities in different types of human brain tumours. A quantitative autoradiography study
25. Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods
26. Imaging of brain tumors using peripheral benzodiazepine receptor ligands
27. Rapid colorimetric assay for cellular growth survival application to proliferation cytotoxicity assays
28. Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities
29. Peripheral-type benzodiazepine receptor (PBR) in human breast cancer correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation nuclear transport of cholesterol
30. Location-dependent role of the human glioma cell peripheral-type benzodiazepine receptor in proliferation steroid biosynthesis
31. Micromolar-affinity benzodiazepine receptors regulate voltage-sensitive calcium channels in nerve terminal preparations