Proposed reductive metabolism of artemisinin by glutathione transferases in vitro

Free Radical Research

Volumn 35, Issue 4, 2001, Pages 427-434

  Mukanganyama, Stanley ^a   Naik, Yogeshkumar S ^a   Widersten, Mikael ^b   Mannervik, Bengt ^a   Hasler, Julia A ^a  

^a UNIVERSITY OF ZIMBABWE   (Zimbabwe)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Artemisinin; Glutathione transferases; Metabolism; NADPH; Reduction

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; ANTIMALARIAL AGENT; ARTEMISININ; ASCORBIC ACID; CUMENE HYDROPEROXIDE; ENDOPEROXIDE; FREE RADICAL; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HYDROPEROXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SESQUITERPENE LACTONE DERIVATIVE; XENOBIOTIC AGENT;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; ASSAY; BINDING AFFINITY; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; CYTOSOL; DRUG DETOXIFICATION; DRUG METABOLISM; DRUG RESISTANCE; DRUG STRUCTURE; DRUG USE; ENZYME ACTIVITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; INTESTINE; KIDNEY; LIVER CYTOSOL; MALE; MODEL; NONHUMAN; PHARMACOKINETICS; PLASMODIUM FALCIPARUM; PROTEIN EXPRESSION; RAT;

EID: 0034834377     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760100300941     Document Type: Article

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