The relationship between metformin therapy and the fasting plasma lactate in type 2 diabetes: The fremantle diabetes study

British Journal of Clinical Pharmacology

Volumn 52, Issue 2, 2001, Pages 137-144

  Davis, Timothy M E ^a   Jackson, Denise ^a   Davis, Wendy A ^a   Bruce, David G ^a   Chubb, Paul ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b FREMANTLE HOSPITAL   (Australia)

Author keywords

Factor analysis; Metformin; Plasma lactate; Type 2 diabetes

Indexed keywords

BICARBONATE; GLUCOSE; LACTIC ACID; METFORMIN;

ADULT; AGED; ARTICLE; BICARBONATE BLOOD LEVEL; BODY MASS; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FACTORIAL ANALYSIS; FEMALE; GLUCOSE BLOOD LEVEL; HEMODYNAMICS; HUMAN; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PULSE RATE; SYMPATHETIC TONE;

AGED; DIABETES MELLITUS, TYPE 2; FASTING; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; LACTIC ACID; MALE; METFORMIN; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 0034833443     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0306-5251.2001.01423.x     Document Type: Article

References (32)

1. UKPDS 28: A randomised trial of efficacy of early addition of metformin in sulphonylurea-treated non-insulin dependent diabetes
2. UKPDS 34: Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes
3. A risk-benefit assessment of metformin in type 2 diabetes mellitus
4. Metformin-associated lactic acidosis in Sweden 1977-1991
5. Role of metformin accumulation in metformin-associated lactic acidosis
6. Lactic acidosis in patients with diabetes treated with metformin
7. Metformin and the sulphonylureas: The comparative risk
8. Lactic acidosis rates in type 2 diabetes
9. Contraindications to metformin therapy in patients with NIDDM
10. Contra-indications to metformin therapy in patients with diabetes: A population-based study
11. Non-steroidal anti-inflammatory drugs and metformin: A cause for concern?
12. Possible synergistic effect of metformin and enalapril on the development of hyperkaliemic lactic acidosis
13. Treatment of lactic acidosis with dichloroacetate
14. Metformin
15. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
16. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus
17. Role of metformin in treatment of diabetes mellitus
18. Effects of metformin on the pathways of glucose utilization after oral glucose in non-insulin-dependent diabetes mellitus patients
19. Diurnal pattern of plasma metformin concentrations and its relation to metabolic effects in type 2 (non-insulin-dependent) diabetic patients
20. A comparison of treatment with metformin and gliclazide in patients with non-insulin-dependent diabetes
21. Blood lactate and pyruvate levels in diabetic patients treated with biguanides with and without sulphonylureas
22. Response of insulin, glucagon, lactate, and nonesterified fatty acids to glucose in visceral obesity with and without NIDDM, relationship to hypertension
23. Relationship between blood pressure, metabolic variables and blood flow in obese subjects with or without non-insulin-dependent diabetes mellitus
24. Biguanide-associated lactic acidosis. Case report and review of the literature
25. Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM
26. Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis
27. Reduction of plasma catecholamines in humans during clinically controlled severe underfeeding
28. Metformin improves hemodynamic and rheological responses to L-arginine in NIDDM patients
29. Use of serum creatinine concentrations to determine renal function
30. An overview of body weight of older persons, including the impact on mortality. The National Health and Nutrition examination survey I - Epidemiologic follow-up study
31. Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus